非编码RNA在血管重塑中的作用  

The role of non-coding RNA in vascular remodeling

作　　者：荆玉辰[1] 孙伟峰 辛世杰[1] 吴文颖[2] JING Yu-chen;SUN Wei-feng;XIN Shi-jie;WU Wen-ying(Department of Vascular Surgery/Department of Thyroid Surgery, Key Laboratory of Pathogenesis, Prevention and Therapeutics of Aortic Aneurysm, Shenyang 110001, China;Department of Radiology the First Affiliated Hospital of China Medical University, Shenyang 110001, China)

机构地区：[1]中国医科大学附属第一医院血管外科/甲状腺外科/辽宁省动脉瘤疾病病因及防治研究重点实验室,辽宁沈阳110001 [2]中国医科大学附属第一医院放射科,辽宁沈阳110001

出　　处：《解剖科学进展》2019年第4期487-490,共4页Progress of Anatomical Sciences

基　　金：国家自然科学基金(81770488)

摘　　要：血管重塑是一种动态的血管结构与功能的改变,其发生过程涉及增殖、迁移、凋亡及细胞外基质合成与降解等细胞演变过程,包括高血压、肺动脉高压以及主动脉瘤等疾病均为血管重塑性疾病。研究发现,LncRNA在血管重塑中有着各种影响,如RNCR3上调有自我修复的表现,H19可导致血管重塑等。不同的microRNA在血管重塑中也有着不同作用,如miR-23/24/27、miR-143/145抑制血管再狭窄、miR-17-92作为潜在治疗靶点等。Vascular remodeling is a dynamic change of vascular structure and function. Its occurrence involves cell evolution processes such as proliferation, migration, apoptosis and synthesis and degradation of extracellular matrix. Diseases such as hypertension, pulmonary hypertension and aortic aneurysm are all vascular remodeling diseases. LncRNA has a variety of effects in vascular remodeling, such as the upregulation of RNCR3 with self-repair, and H19 leads to vascular remodeling. Different micrornas also have different roles in vascular remodeling, such as mir-23/24/27, mir-143/145 inhibiting vascular restenosis, and mir-17-92 as potential therapeutic targets.

关 键 词：MIRNA 平滑肌细胞 染色体 RNA MICRORNA 颈动脉球囊损伤 

分 类 号：R329.3[医药卫生—人体解剖和组织胚胎学]