中药成分抗真菌机制研究进展  

Research progress of antifungal mechanism of Chinese medicine ingredients

作　　者：赵卜司 贺丹[1] 卫芸芸 王丽[1] ZHAO Bu-Si;HE Dan;WEI Yun-Yun;WANG Li(Department of Pathogenobiology,College of Basic Medical Sciences,Jilin University,Changchun,Jilin 130021,China)

机构地区：[1]吉林大学基础医学院病原生物学系

出　　处：《菌物学报》2019年第8期1230-1234,共5页Mycosystema

基　　金：国家自然科学基金(81772162)~~

摘　　要：目前,寻找新型抗真菌药物迫在眉睫。已有研究表明,有效中药成分具有良好的抗真菌作用,可能具有应用前景。本文综述了抗真菌中药及其抗真菌的主要机制,涉及干扰物质运输、酵母-菌丝相转化、宿主免疫和氧化还原等方面,为中药及其提取物在抗真菌中的应用提供了一定的指导。At present,fungal infection is more and more common and serious,but the clinical usage of antifungal drugs is limited by their toxic and side effects,which may be valuable in use in the future.This paper reviews the main mechanisms of antifungal effects of Chinese medicine ingredients,concerning interfering substance transport,yeast-to-hypha transition,host immunity,redox and others,for purposes of providing reference material for application of Chinese medicine in antifungal treatment.

关 键 词：细胞膜 酵母-菌丝相转化 宿主免疫 能量代谢 氧化应激 

分 类 号：R285[医药卫生—中药学]