基质金属蛋白酶-10与内分泌代谢疾病的相关性  

Correlation between matrix metalloproteinase-10 and endocrine metabolism disorders

作　　者：崔冉[1] 许小娟 周玲玲 韩玉麒[1] 曲伸[1] 盛辉[1] CUI Ran;XU Xiao-juan;ZHOU Ling-ling;HAN Yu-qi;QU Shen;SHENG Hui(Department of Endocrinology and Metabolism,Tenth People's Hospital of Tongji University,Shanghai 200072,China)

机构地区：[1]同济大学附属第十人民医院内分泌及代谢病科

出　　处：《中华骨质疏松和骨矿盐疾病杂志》2019年第4期388-394,共7页Chinese Journal Of Osteoporosis And Bone Mineral Research

基　　金：国家自然科学基金青年基金项目(81500650);同济大学附属第十人民医院攀登人才计划(2018SYPDRC049)

摘　　要：基质金属蛋白酶(matrix metalloproteinase,MMP)是依赖Zn^2+的内源性蛋白水解酶,几乎可以降解细胞外所有基质。MMP-10属于其中的间充质溶解素类,主要降解蛋白多糖、纤维黏连蛋白等。很多激素和细胞因子可以改变其表达情况,如性激素、糖皮质激素、甲状腺素、白细胞介素-1、白细胞介素-6、肿瘤坏死因子-α等。目前,有研究发现,MMP-10可以参与糖尿病视网膜病变、糖尿病肾病、脂代谢异常、血管性疾病和代谢性骨病等多种内分泌代谢疾病的发生、发展、转归。Matrix metalloproteinases (MMPs) are zinc-containing endopeptidases and can degrade almost all extracellular matrix. Matrix metalloproteinase-10 belongs to the mesenchymal lysin group, mainly degrading proteoglycan and fibronectin. Many hormones and cytokines can change its expression, such as sex hormone, glucocorticoid, thyroid hormone, interleukin-1, interleukin-6, tumor necrosis factor -α, etc. At present, studies have found that matrix metalloproteinase-10 can be involved in the occurrence, development, and outcome of diabetic retinopathy, diabetic nephropathy, abnormal lipid metabolism, vascular disease, metabolic bone disease, and so on.

关 键 词：基质金属蛋白酶 基质金属蛋白酶-10 间充质溶解素 蛋白多糖 纤维黏连蛋白 性激素 糖皮质激素 

分 类 号：R589[医药卫生—内分泌]