不同年龄段多发性创伤骨折患者围术期凝血及血小板功能的变化  

Change of perioperative blood coagulation and platelet function in patients with multiple traumatic fractures of different age groups

作　　者：吴泽 刘雄伟[2] WU Ze;LIU Xiong-wei(Department of Clinical Laboratory, Orthopaedic Hospital of Longgang District in Shenzhen City, Guangdong Province, Shenzhen 518000, China;Department of Clinical Laboratory, Longgang Central Hospital of Shenzhen City, Guangdong Province, Shenzhen 518000, China)

机构地区：[1]深圳市龙岗区骨科医院检验科,广东深圳518000 [2]深圳市龙岗中心医院检验科,广东深圳518000

出　　处：《中国当代医药》2019年第24期134-136,共3页China Modern Medicine

摘　　要：目的探讨不同年龄段多发性创伤骨折患者围术期凝血及血小板功能的变化。方法选取深圳市龙岗区骨科医院2017年6月~2018年10月收治的200例行外科手术治疗的多发性创伤骨折患者,按照不同年龄段进行分组,分成青年组(A组,72例)、中年组(B组,60例)和老年组(C组,68例)。观察三组术前(T0)、术后1d(T1)、术后3d(T2)内的凝血功能指标:纤维蛋白原(FIB)、凝血酶时间(TT)、活化部分凝血活酶时间(APTT)及凝血酶原时间(PT);并检测血小板参数:血小板分布宽度(PDW)、血小板计数(PLT)、血小板积压(PCT)及血小板平均体积(MPV)。结果三组T2时的FIB、TT、APTT、PT指标及T0~T1时的TT指标比较,差异无统计学意义(P>0.05);C组T0~T1时的APTT、PT短于A、B组,B组短于A组,差异均有统计学意义(P<0.05),C组的FIB水平高于A、B组,B组高于A组,差异均有统计学意义(P<0.05);三组T1、T2时的FIB水平低于T0时,差异有统计学意义(P<0.05),三组T1、T2时的APTT、PT均长于T0时,差异有统计学意义(P<0.05)。三组T0~T2时的PDW、PCT及MPV比较,差异无统计学意义(P>0.05);T0~T2时,C组的PLT水平低于A、B组,B组低于A组,差异均有统计学意义(P<0.05);三组T1、T2时的PLT水平低于T0时,差异有统计学意义(P<0.05)。结论与青年、中年人群比较,老年多发性创伤骨折患者围术期内容易出现凝血及血小板参数异常情况,发生血栓等并发症的风险较大。Objective To investigate the change of perioperative blood coagulation and platelet function in patients with multiple traumatic fractures of different age groups. Methods From June 2017 to October 2018, 200 patients with multiple traumatic fractures treated surgically in Orthopaedic Hospital of Longgang District in Shenzhen City were selected and they were divided into young group (group A, 72 cases), middle-aged group (group B, 60 cases) and old group (group C, 68 cases). The coagulation function indexes including fibrinogen (FIB), thrombin time (TT), activated partial thromboplastin time (APTT) and prothrombin time (PT) were observed before operation (T0), 1 day (T1) and 3 days (T2) after operation in three groups, and the platelet parameters including platelet distribution width (PDW), platelet count (PLT), platelet backlog (PCT) and mean platelet volume (MPV) were measured. Results There were no significant differences in FIB, TT, APTT, PT at T2 and TT at T0-T1 among the three groups (P>0.05). The APTT and PT of group C at T0-T1 were shorter than those of group A and B, and those of group B were shorter than those of group A, with statistical differences (P<0.05). FIB level of group C was higher than that of group A and B, and that of group B was higher than that of group A, with statistical differences (P<0.05). FIB level at T1 and T2 was lower than that at T0, and the differences were statistically significant (P<0.05). APTT and PT at T1 and T2 were longer than those at T0, and the differences were statistically significant (P<0.05). There were no significant differences in PDW, PCT and MPV among the three groups at T0-T2 (P>0.05);at T0-T2, PLT level of group C was lower than that of group A and B, and that of group B was lower than that of group A, with statistical differences (P<0.05);at T1 and T2, PLT level of the three groups was lower than that at T0, and the differences were statistically significant (P<0.05). Conclusion Compared with young and middle-aged people, elderly patients with multiple traum

关 键 词：多发性创伤骨折 凝血 血小板功能 不同年龄段 

分 类 号：R683[医药卫生—骨科学]