24 h持续光疗治疗新生儿高胆红素血症的效果及安全性分析  

Efficacy and Safety of 24-hour Continuous Phototherapy for Neonatal Hyperbilirubinemia

作　　者：任静 REN Jing(Zhuxi County People’s Hospital,Zhuxi 442300,China)

机构地区：[1]竹溪县人民医院

出　　处：《中外医学研究》2019年第24期168-170,共3页CHINESE AND FOREIGN MEDICAL RESEARCH

摘　　要：目的:探析24 h持续光疗治疗新生儿高胆红素血症的效果及安全性。方法:选取高胆红素血症新生儿114例,随机分为持续组(55例)及间歇组(59例)。持续组行24 h持续光疗,间断组行持续光疗10 h、休息14 h×2 d的间断光疗。比较两组疗效及安全性,观察患儿血清总胆红素(TBS)及经皮胆红素(TcB)水平变化。结果:两组临床总有效率比较差异无统计学意义(P>0.05),间歇组不良反应发生率低于持续组,差异有统计学意义(P<0.05)。两组治疗前后TBS、TcB水平差异无统计学意义(P>0.05),两组治疗后TBS、TcB水平均较治疗前降低(P<0.05)。结论:24 h持续光疗与间断光疗均可有效治疗新生儿高胆红素血症,但24 h持续光疗安全性低于间断光疗。Objective:To analyze the effect and safety of 24 h continuous phototherapy in the treatment of neonatal hyperbilirubinemia.Method:A total of 114 neonates with hyperbilirubinemia were randomly divided into continuous group(55 cases) and intermittent group(59 cases).The continuous group received 24 hours continuous phototherapy,while the intermittent group received 10 hours continuous phototherapy and 14 hours rest×2 days.The efficacy and safety of the two groups were compared,and the changes of serum total bilirubin(TBS) and transdermal bilirubin(TcB) levels were observed.Result:There was no significant difference in the total effective rate between the two groups(P>0.05),and the incidence of adverse reactions in the intermittent group was lower than that in the continuous group(P<0.05).There was no significant difference in the levels of TBS and TcB between the two groups before and after treatment(P>0.05),and the levels of TBS and TcB in the two groups after treatment were lower than those before treatment(P<0.05).Conclusion:24-hour continuous phototherapy and intermittent phototherapy can effectively treat neonatal hyperbilirubinemia,but 24-hour continuous phototherapy is less safe than intermittent phototherapy.

关 键 词：高胆红素血症 新生儿 持续光疗 间歇光疗 

分 类 号：R722.1[医药卫生—儿科]