CT引导下125I粒子植入术联合肝动脉导管化疗栓塞术治疗原发性肝癌的效果  

Effect of CT-guided 125I seed implantation combined with hepatic arterial chemoembolization in the treatment of primary liver cancer

作　　者：刘金朝 LIU Jin-chao(Interventional Medicine Department, Puyang Oilfield General Hospital, Puyang 457000, China)

机构地区：[1]河南省濮阳市油田总医院介入科

出　　处：《临床医学研究与实践》2019年第24期59-60,共2页Clinical Research and Practice

摘　　要：目的探讨CT引导下^125I粒子植入术联合肝动脉导管化疗栓塞术治疗原发性肝癌的效果。方法选取我院收治的原发性肝癌患者80例,采用随机数字表抽取法将其分为观察组与对照组,各40例。对照组单用肝动脉导管化疗栓塞术治疗,观察组在此基础上联用CT引导下^125I粒子植入术治疗。比较两组临床病情缓解率、门静脉主干直径、不良反应发生情况及近期生存率。结果观察组临床病情缓解率高于对照组(P<0.05)。治疗后,两组门静脉主干直径均缩小,且观察组小于对照组(P<0.05)。两组转氨酶异常、呕吐及骨髓抑制不良反应发生率均无显著差异(P>0.05)。观察组近期生存率高于对照组(P<0.05)。结论CT引导下125I粒子植入术联合肝动脉导管化疗栓塞术治疗原发性肝癌可提高患者的临床缓解率及近期生存率,解除门静脉高压,且未明显增加骨髓抑制、胃肠道等不良反应。Objective To investigate the effect of CT -guided ^125I seed implantation combined with hepatic arterial chemoembolization for primary liver cancer. Methods A total of 80 patients with primary liver cancer admitted in our hospital were selected and divided into observation group and control group by random number table extraction method, with 40 cases in each group. The control group was treated with hepatic arterial chemoembolization alone, while the observation group was treated with CT-guided 125I seed implantation on this basis. The clinical condition remission rate, diameter of the main portal vein, adverse reactions and short-term survival rate were compared between the two groups. Results The clinical condition remission rate of the observation group was higher than that of the control group (P<0.05). After treatment, the diameter of the main portal vein in both groups decreased, and that in the observation group was smaller than the control group (P<0.05). There were no significant differences in the incidence of abnormal transaminase, vomiting and bone marrow suppression between the two groups (P>0.05). The short-term survival rate of the observation group was higher than that of the control group (P<0.05). Conclusion CT-guided ^125I seed implantation combined with hepatic arterial chemoembolization can improve the clinical remission rate and short-term survival rate, relieve portal hypertension of patients, and no significant increasing in bone marrow suppression, gastrointestinal and other adverse reactions.

关 键 词：原发性肝癌 肝动脉导管化疗栓塞术 CT引导下^125I粒子植入术 

分 类 号：R735.7[医药卫生—肿瘤]