肝纤维化肝脏ADC值与病理的对照分析  

Comparative analysis of apparent diffusion coefficient and pathological staging in liver fibrosis

作　　者：刘春堂[1] 李若旭[1] 邢卫红[1] 崔树彦[1] 董春娇[1] 赵子龙[1] LIU Chuntang;LI Ruoxu;XING Weihong(Department of Radiology,The Fifth Hospital of Shijiazhuang City,Hebei,Shijiazhuang 050021,China)

机构地区：[1]河北省石家庄市第五医院放射科

出　　处：《河北医药》2019年第18期2778-2781,共4页Hebei Medical Journal

基　　金：石家庄市科学技术研究与发展计划项目(编号:161462223)

摘　　要：目的探讨肝脏磁共振扩散加权成像(diffusion weighted imaging,DWI)及表观扩散系数(apparent diffusion coefficient,ADC)值对肝纤维化的诊断及其分级的价值。方法对76例经穿刺病理确诊乙型肝炎患者(疾病组)及20例正常人(对照组)进行肝脏磁共振DWI扫描,将疾病组与对照组肝脏ADC值进行比较,并对照分析疾病组肝脏ADC值与肝纤维化病理分期之间的相关性。结果疾病组肝脏ADC值与对照组比较,差异有统计学意义( P <0.05)。而肝纤维化S1~S4期ADC值比较差异无统计学意义( P >0.05)。结论 肝脏ADC值并不能有效区分肝纤维化(S1~S4)不同分期,但对判断肝纤维化及非肝纤维化具有较高的临床价值,可以作为无创性诊断肝纤维化的辅助方法。Objective To investigate the application value of diffusion weighted imaging(DWI) and apparent diffusion coefficient(ADC) in diagnosis and grading of liver fibrosis.Methods The liver DWI scanning was performed in 76 patients with hepatitis B that was confirmed by biopsy(case group) and 20 healthy subjects(control group).The ADC value was compared between case group and control group,moreover,the correlation between liver ADC and pathological stages of liver fibrosis was analyzed.Results There was significant difference in liver ADC value between case group and control group(P<0.05), which in case group was significantly lower than that in control group.However, there was no significant differnce in liver ADC value among S1~S4 stages of liver fibrosis(P>0.05).Conclusion The liver ADC value can not be used to distinguish the different stages(S1~S4) of hepatic fibrosis,but it has higher clinical value in diagnosis of liver fibrosis,which can be used as an assistant method in non-invasive diagnosis of liver fibrosis.

关 键 词：肝纤维化 弥散加权成像 DWI ADC值肝脏穿刺活检 

分 类 号：R445.2[医药卫生—影像医学与核医学]