中老年女性骨代谢指标与骨质疏松的相关性研究  

Correlation between Bone Metabolic Markers and Osteoporosis in Middle-aged and Elderly Women

作　　者：罗巧彦 凌止发 严宗逊[1] 陈敏[1] 李玲[1] 彭乙华[1] 黄晓佳[1] LUO Qiao-yan;LING Zhi-fa;YAN Zong-xun;CHEN Min;LI Ling;PENG Yi-hua;HUANG Xiao-jia(Department of Endocrinology,Affiliated Hospital of North Sichuan Medical College,Nanchong 637000,Sichuan,China;Department of Blood Transfusion,Affiliated Hospital of North Sichuan Medical College,Nanchong 637000,Sichuan,China)

机构地区：[1]川北医学院附属医院内分泌科,四川南充637000 [2]川北医学院附属医院输血科,四川南充637000

出　　处：《医学信息》2019年第17期68-71,共4页Journal of Medical Information

摘　　要：目的分析骨代谢指标与骨质疏松的关系,为骨质疏松的防治提供流行病学依据。方法采取随机分层抽样方法,选取2018年1月~5月来我院健康体检的30~90岁的成年女性400名。采用双能X线吸收测量仪(DEXA)测量腰椎及左侧股骨骨密度,由调查人员对所有体检对象进行问卷调查,同时收集清晨空腹血检测血常规、肝肾功、骨吸收指标TRAP-5b、CTX、N-MID及骨形成指标BAP、PⅠNP等资料,进行统计学分析。结果①我院30岁以上女性骨质疏松的检出率为55.28%;②骨质疏松人群平均年龄为(63.54±9.40)岁,大于骨量减少人群的(49.42±9.51)岁和骨量正常人群的(44.14±6.71)岁,差异有统计学意义(P<0.05);年龄与骨密度存在相关性;③骨质疏松人群TRAP-5b、CTX、BAP水平大于骨量减少和骨量正常人群,均与骨密度存在相关性;N-MID、PⅠNP在骨质疏松人群、骨量减少和骨量正常人群中比较,差异无统计学意义(P>0.05),与骨密度无相关性;④年龄升高是骨质疏松的危险因素,而超重和肥胖可能是骨质疏松的保护因素。⑤以年龄>55岁来预测骨质疏松的敏感性和特异性分别为82.52%,81.48%;而以BAP>17.7μg/L来预测骨质疏松的敏感性和特异性分别为53.84%,73.65%。结论中老年女性骨质疏松的检出率较高,年龄升高是骨质疏松的危险因素,骨密度与骨代谢指标TRAP-5b、CTX、BAP呈负相关。Objective Analysis of the relationship between bone metabolic markers and osteoporosis provides an epidemiological basis for the prevention and treatment of osteoporosis.Methods A randomized stratified sampling method was used to select 400 adult women aged 30-90 who were admitted to our hospital from January to May 2018.The dual-energy X-ray absorptiometry(DEXA)was used to measure the bone mineral density of the lumbar vertebrae and the left femur.The investigators conducted a questionnaire survey on all the subjects,and collected the early morning fasting blood test for blood routine,liver and kidney function,and bone resorption index TRAP-5b,CTX,N-MID and bone formation indicators BAP,PINP and other data for statistical analysis.Results①The detection rate of osteoporosis in women over 30 years old in our hospital was 55.28%;②The average age of osteoporosis population was(63.54±9.40)years old,which was greater than that of people with reduced bone mass(49.42±9.51)years old and those with normal bone mass(44.14±6.71)years old,the difference was statistically significant(P<0.05).Age is related to bone mineral density;③The levels of TRAP-5b,CTX and BAP in osteoporosis population were higher than those with normal bone mass and normal bone mass,and were associated with bone mineral density.N-MID and PINP were in osteoporosis population,bone mass loss and normal bone mass.There was no significant difference between the two groups(P>0.05)and no correlation with bone mineral density.④Elevated age is a risk factor for osteoporosis,and overweight and obesity may be protective factors for osteoporosis.⑤The sensitivity and specificity of predicting osteoporosis at age>55 years were 82.52%and 81.48%,respectively.The sensitivity and specificity of predicting osteoporosis with BAP>17.7μg/L were 53.84%and 73.65%,respectively.Conclusion The detection rate of osteoporosis is higher in middle-aged and elderly women.Age is a risk factor for osteoporosis.Bone mineral density is negatively correlated with bone metabol

关 键 词：骨质疏松 骨代谢标志物 中老年女性 

分 类 号：R589.9[医药卫生—内分泌]