清咽颗粒的主要药效学实验研究  

Experimental study on pharmacodynamic of qingyan granules

作　　者：赵丽艳 李明春 马燕 程艳芹 ZHAO Li-yan;LI Ming-chun;MA Yan;CHENG Yan-qin(No. 971 Hospital of the PLA,Shandong Qingdao 266071,China)

机构地区：[1]解放军海军第971医院

出　　处：《海南医学院学报》2019年第17期1314-1318,共5页Journal of Hainan Medical University

基　　金：军队医疗机构制剂标准提高科研专项课题重点项目(13ZJZ03,14ZJZ02)~~

摘　　要：目的:对清咽颗粒的主要药效学进行考察。方法:进行小鼠的最大耐受量实验、建立小鼠耳廓肿胀模型、大鼠足肿胀模型、热板法致小鼠疼痛模型、小鼠醋酸扭体模型以及小鼠气管段酚红排泌法祛痰模型,考察清咽颗粒的毒性反应、抗炎、镇痛以及祛痰的药效。结果:清咽颗粒最大给药量为42 g/kg,相当于人的56倍,本制剂对二甲苯引起的小鼠耳廓肿胀具有显著的抑制作用,对角叉菜胶引起的大鼠足肿胀具有显著的抑制作用,对由于热刺激而导致的小鼠疼痛有显著的抑制作用,能明显延长由于醋酸刺激而引起小鼠疼痛反应时间,对由于化学刺激而导致的小鼠疼痛有显著的抑制作用。结论:清咽颗粒具有抗炎、镇痛、祛痰等方面的作用。Objective: To investigate the pharmacodynamics of Qingyan granules. Methods: To investigate the efficancy of qingyan granules, the animal experience of maximum tolerated dose of mice was made. And the auricular swelling model of mice, the foot swelling model of rat, the phenol red secretion method, and the hot-plate and glacial acetic acid stimulation writhing method was established and used to test the anti-inflammatory effect, the expectorant effect, and the analgesia effect. Results: Pharmacodynamics experiment proved that the maximum dosage for mice was 42 g/kg, the equivalent of 56 times for human. Qingyan granules has obvious inhibitory effect on mouse auricle swelling caused by xylene, and has obvious inhibitory effect on carrageenan-induced rat paw edem. Also, the mice pain caused by thermal and chemical stimulation has obviously inhibited by Qingyan granules. Qingyan granules can prolong the pain reaction time on mice caused by acetic acid. Conclusions: Qingyan granules have evident effects of anti-inflammatory effect, analgesic effect and expectorant effect.

关 键 词：清咽颗粒 抗炎作用 镇痛作用 祛痰作用 

分 类 号：R285.5[医药卫生—中药学]