参芪养心颗粒对冠脉结扎致犬急性心肌缺血影响的实验研究  

Experimental study on effect of Shenqi Yangxin Granule on dogs with acute myocardial ischemia caused by coronary ligation

作　　者：韩晓江[1] 杜锦辉[1] 关敬之 毕连宝[1] 刘雁飞[3] 呼格吉乐[4] HAN Xiaojiang;DU Jinhui;GUAN Jingzhi;BI Lianbao;LIU Yanfei;Hugejile(Department of Traditional Chinese Medicine,The Affiliated Hospital of Inner Mongolia Medical University,Hohhot 010059,China;Department of Pharmacy,Inner Mongolia International Mongolian Hospital,Hohhot 010065,China;Department of Imaging,The Affiliated Hospital of Inner Mongolia Medical University,Hohhot 010059,China;Department of Clinical Laboratory, The Affiliated Hospital of Inner Mongolia Medical University,Hohhot 010059,China)

机构地区：[1]内蒙古医科大学附属医院中医科,呼和浩特010059 [2]内蒙古国际蒙医医院,内蒙古医科大学附属蒙医医院药学部,呼和浩特010065 [3]内蒙古医科大学附属医院影像科,呼和浩特010059 [4]内蒙古医科大学附属医院检验科,呼和浩特010059

出　　处：《天津中医药》2019年第9期916-920,共5页Tianjin Journal of Traditional Chinese Medicine

基　　金：2017年度内蒙古自治区卫生计生科研项目(201702014)

摘　　要：[目的]研究参芪养心颗粒对冠脉结扎致犬急性心肌缺血的影响。[方法]冠脉结扎致犬急性心肌缺血,观察参芪养心颗粒对犬心肌缺血区心外膜电图(N-ST)、冠脉血管阻力(CVR)、心肌血流量(MBF)、心肌耗氧量(MOC)、左心室心肌细胞苏木精-伊红(HE)染色病理变化以及心肌梗死区质量的影响。[结果]与模型对照组比较参芪养心颗粒中剂量组(5.46 g生药/kg)和参芪养心颗粒高剂量组(10.92 g生药/kg)可显著降低犬心肌缺血区N-ST。与模型对照组比较参芪养心颗粒中剂量组(5.46 g生药/kg)和参芪养心颗粒高剂量组(10.92 g生药/kg)可显著降低冠脉血管阻力。与模型对照组比较参芪养心颗粒中剂量组(5.46 g生药/kg)和参芪养心颗粒高剂量组(10.92 g生药/kg)可显著增加犬急性心肌缺血模型的心肌血流量。与模型对照组比较参芪养心颗粒高剂量组(10.92 g生药/kg)可显著降低心肌耗氧量。与模型对照组比较参芪养心颗粒中剂量组(5.46g生药/kg)和参芪养心颗粒高剂量组(10.92 g生药/kg)可显著降低心肌梗死区质量。[结论]参芪养心颗粒对冠脉结扎致犬急性心肌缺血模型具有保护作用。[Objective] To study the effects of Shenqi Yangxin Granule on acute myocardial ischemia in dogs induced by coronary artery ligation.[Methods] Acute myocardial ischemia was induced by coronary artery ligation. The effects of Shenqi Yangxin Granule on N-ST,coronary vascular resistance,myocardial blood flow,myocardial oxygen consumption and myocardial infarct size were observed.[Results]Compared with the model control group,the Shenqi Yangxin granules in the middle dose group(5.46 g crude drug/kg) and the Shenqi Yangxin Granule high dose group(10.92 g crude drug/kg) significantly reduced the N-ST in the canine myocardial ischemic area.Compared with the model control group,the Shenqi Yangxin Granules middle dose group(5.46 g crude drug/kg) and Shenqi Yangxin Granule high dose group(10.92 g crude drug/kg) can significantly reduce coronary vascular resistance. Compared with the model control group,the Shenqi Yangxin Granule middle dose group(5.46 g crude drug/kg) and the Shenqi Yangxin Granule high dose group(10.92 g crude drug/kg) significantly increased myocardial blood flow in the canine acute myocardial ischemia model. Compared with the model control group,the high dose group of Shenqi Yangxin Granule(10.92 g crude drug/kg) can significantly reduce myocardial oxygen consumption. Compared with the model control group,the Shenqi Yangxin Granule middle dose group(5.46 g crude drug/kg) and the Shenqi Yangxin Granule high dose group(10.92 g crude drug/kg) can significantly reduce the area of myocardial infarction.[Conclusion] Shenqi Yangxin Granule has protective effect on acute myocardial ischemia induced by coronary artery ligation.

关 键 词：参芪养心颗粒 急性心肌缺血 BEAGLE犬 

分 类 号：R541.4[医药卫生—心血管疾病]