降糖藏药康珠甘露总黄酮口服前体脂质体的制备及质量评价  

Preparation and Quality Evaluation of Oral Proliposomes of Total Flavonoids from Hypoglycemic Tibetan Medicine KangZhuGanLu

作　　者：孟达 毛羽[1] 林灵敏 卓小月 蒋孝龙 MENG Da;MAO Yu;LIN Lingmin;ZHUO Xiaoyue;JIANG Xiaolong(Pharmacy College,Southwest Minzu University,Chengdu 610041,China)

机构地区：[1]西南民族大学

出　　处：《中国民族民间医药》2019年第15期25-30,共6页Chinese Journal of Ethnomedicine and Ethnopharmacy

基　　金：西南民族大学大学生创新项目(201810656057)

摘　　要：目的:制备降糖藏药康珠甘露总黄酮(ZYZH)口服固体前体脂质体并对其进行质量评价。方法:采用山梨醇载体沉积法ZYZH前体脂质体,以包封率为评价指标,采用单因素考察和正交试验法,优化ZYZH前体脂质体处方及制备方法及工艺,考察ZYZH前体脂质体的形态、粒径分布、Zeta电位及稳定性。结果:ZYZH前体脂质体的最优处方如下:药脂比1∶10,磷脂胆固醇比5∶1,制备温度为40℃;所形成的前体脂质体外观饱满、致密,复水后粒径为(442.5±3.5)nm(PDI=0.177),Zeta电位值为(-47.2±3.4)mV,包封率为(67.5±0.1),贮存期间(30d)稳定性较好。结论:山梨醇载体沉积法制备的ZYZH前体脂质体工艺简单、包封率高、稳定性好,值得进一步研究。可为后期制剂学研究提供依据。Objective To prepare and evaluate the quality of oral ZYZH dry granular proliposomes. Methods ZYZH proliposomes were prepared by carrier deposition method,The formulation, preparation method and technology of ZYZH precursor liposomes were optimized by single factor and orthogonal test. The particle morphology, size distribution, Zeta potential, encapsulation efficiency and stability of ZYZH precursor liposomes were investigated. Result The optimum formulation of ZYZH dry granular proliposomes is as follows:1∶ 10 lipid ratio, 5∶ 1 phospholipid cholesterol ratio and 40 C. The prepared proliposomes were plump and compact in vitro, with a particle size of (442.5±3.5)nm (PDI=0.177), Zeta potential value of (-47.2±3.4)mV, encapsulation efficiency of (67.5±0.1)and good stability during storage (30 d). Conclusion The preparation of ZYZH precursor liposomes has the advantages of simple process, high encapsulation efficiency and good stability.

关 键 词：前体脂质体 制备方法 正交试验 包封率 

分 类 号：R943.42[医药卫生—药剂学]