乙肝病毒携带对女性不同卵巢储备功能IVF-ET结局的影响  

Effect of hepatitis B virus carrying on the outcome of different ovarian reserve IVF-ET in women

作　　者：蒋宋薇[1] 陈融 李斐文 李柳铭 Jiang Songwei;Chen Rong;Li Feiwen;Li Liuming(Reproductive Medical Research Center,The First Affiliated Hospital of Guangxi Medical University,Nanning 530021,China)

机构地区：[1]广西医科大学第一附属医院生殖中心

出　　处：《广西医科大学学报》2019年第8期1331-1334,共4页Journal of Guangxi Medical University

摘　　要：目的:分析乙肝病毒(HBV)携带对女性不同卵巢储备功能体外受精-胚胎移植(IVF-ET)的胚胎发育及妊娠结局的影响。方法:选取2015年12月至2017年12月广西医科大学第一附属医院收治的216例不孕症患者,其中108例携带HBV(研究组),108例未携带HBV(对照组),再分别根据血清抗苗勒管激素(AMH)水平分为卵巢储备功能低下(AMH<2μg/L)、卵巢储备功能正常(AMH 2~7μg/L)及高卵巢储备功能(AMH>7μg/L)3个亚组。比较两组不同卵巢储备功能患者卵裂率、着床率、正常受精率、优质胚胎率、流产率及临床妊娠率。结果:研究组各个亚组患者无可用胚胎率和流产率均高于对照组(P<0.05);研究组卵巢储备功能正常患者卵裂率、着床率、正常受精率、优质胚胎率、临床妊娠率明显低于对照组卵巢储备功能正常患者(P<0.05),而两组卵巢功能储备低下、高卵巢储备功能患者卵裂率、着床率、正常受精率、优质胚胎率、临床妊娠率比较,差异均无统计学意义(P>0.05)。结论:HBV可通过生殖传播降低卵子的质量,从而影响胚胎发育和妊娠结局。Objective: To analyze the effect of hepatitis B virus (HBV) infection on embryonic development and pregnancy outcome of IVF-ET with different ovarian reserve function in women. Methods: A retrospective analysis of 216 infertile patients in our hospital from December 2015 to December 2017 was carried out.Of them,108 cases were HBV carrier (study group) and 108 cases without HBV (control group).Each group was sub-divided into three groups according to the serum level of anti-Mullerian hormone (AMH): low ovarian reserve function group (AMH<2 μg/L),normal ovarian reserve function group (AMH 2-7 μg/L) and high ovarian reserve function group (AMH>7 μg/L).The cleavage rate,implantation rate,normal fertilization rate,high quality embryo rate,abortion rate and clinical pregnancy rate were compared between the two groups. Results: The rate of unavailable embryos and the abortion rate in each HBV infected sub-group were significantly higher than those without HBV infection respectively ( P <0.05).The cleavage rate,implantation rate,normal fertilization rate,high quality embryo rate and clinical pregnancy rate in HBV-infected patients with normal ovarian reserve function were significantly lower than those without HBV infection ( P <0.05).There was no significant difference in cleavage rate,implantation rate,normal fertilization rate,high quality embryo rate and clinical pregnancy rate among patients with low or high ovarian reserve function ( P >0.05). Conclusion: HBV can reduce the quality of eggs and affect embryonic development,and affect the final pregnancy outcome.

关 键 词：乙肝病毒 IVF-ET 卵巢储备功能 

分 类 号：R512.62[医药卫生—内科学]