载脂蛋白E酶酶基因多态性对肥胖型代谢综合征患者体质量指数及皮下脂肪分布的影响  

Effect of apolipoprotein E enzyme gene polymorphism on BMI index and subcutaneous fat distribution in obese patients with metabolic syndrome

作　　者：王毅[1] 单培仁[2] 黄伟[1] WANG Yi;SHAN Pei-ren;HUANG Wei(Department of Nutrition,the First Affiliated Hospital of Wenzhou Medical University,Wenzhou,Zhejiang 325000,China)

机构地区：[1]温州医科大学附属第一医院营养科,浙江温州325000 [2]温州医科大学附属第一医院心内科,浙江温州325000

出　　处：《中国卫生检验杂志》2019年第17期2057-2059,2067,共4页Chinese Journal of Health Laboratory Technology

基　　金：浙江省自然科学基金项目(LH15H020005)

摘　　要：目的研究载脂蛋白E酶酶基因多态性对肥胖型代谢综合征患者体质量指数(BMI)及皮下脂肪分布的影响。方法选择2016年1月-2017年12月在本院接受诊治的84例肥胖型代谢综合征患者,对其载脂蛋白E酶酶基因多态性、血脂及BMI、皮褶厚度进行检测。结果 H^+H^+-LPL基因型患者的TC、TG、LDL-C、ApoB水平均高于H^+H--LPL基因型患者,差异有统计学意义(P <0.05);但2组患者的HDL-C、ApoA、Lp(a)水平对比,差异无统计学意义(P> 0.05);H^+H^+-LPL基因型患者的BMI及肱二头肌皮褶厚度、肩胛下皮褶厚度、皮褶均数均高于H^+H--LPL基因型患者,差异有统计学意义(P <0.05);但2组患者的腹壁皮褶厚度对比,差异无统计学意义(P> 0.05)。结论载脂蛋白E酶酶基因多态性对肥胖型代谢综合征患者的BMI及血脂水平、机体各部位脂肪分布存在重要影响,为引起肥胖、血脂异常的主要风险基因。Objective To study the effect of apolipoprotein E enzyme gene polymorphism on BMI index and subcutaneous fat distribution in obese metabolic syndrome patients. Methods 84 patients with obesity-type metabolic syndrome who were treated in our hospital from January 2016 to December 2017 were enrolled in the study. The apolipoprotein E enzyme gene polymorphism,blood lipids,BMI,and skinfold thickness were detected. Results The levels of TC,TG,LDL-C and ApoB in H + H+-LPL genotype patients were higher than those in H + H-LPL genotypes,and the differences were statistically significant ( P < 0.05). HDL-C,ApoA,Lp(a) levels were not statistically significant ( P > 0.05);BMI and biceps skinfold thickness,scapular pleat thickness,and skinfold in H+ H+-LPL genotype patients were higher than those of H + H--LPL genotypes,and the difference was statistically significant ( P < 0.05). However,there was no statistical significance on the difference in the thickness of abdominal wall folds between the two groups ( P > 0.05). Conclusion The apolipoprotein E enzyme gene polymorphism has important effects on BMI and blood lipid levels in patients with obesity-type metabolic syndrome,and fat distribution in various parts of the body,and it is the main risk gene for obesity and dyslipidemia.

关 键 词：载脂蛋白E酶酶基因多态性 肥胖型代谢综合征 体质量指数 皮下脂肪分布 

分 类 号：R589[医药卫生—内分泌]