In vivo optical bioimaging by using Nd-doped LaF3 luminescent nanorods in the second near-infrared window  

作　　者：Shouyan Cheng Liu Liu Qiuhua Yang Youbin Li Songjun Zeng 

机构地区：[1]Synergetic Innovation Center for Quantum Effects and Application,Key Laboratory of Low-dimensional Quantum Structures and Quantum Control of Ministry of Education,School of Physics and Electronics,Hunan Normal University

出　　处：《Journal of Rare Earths》2019年第9期931-936,I0002,共7页稀土学报（英文版）

基　　金：Project supported by the National Natural Science Foundation of China(21671064);Science and Technology Planning Project of Hunan Province(2017RS3031)

摘　　要：Fluorescent imaging in the second near-infrared(NIR-Ⅱ,1000-1700 nm)region has attracted enormous research interest due to its advantages of unprecedentedly improved imaging sensitivity and spatial resolution.Herein,high quality NIR-Ⅱemissive LaF3:Nd3+nanorods(NRs)with hexagonal phase structure and controlled size were synthesized by a hydrothermal method.And the Nd^3+doping induced NIRⅡluminescent intensity evolution was studied,In vivo NIR-Ⅱbioimaging and real-time tracking reveal that these LaF3:Nd^3+NRs are mainly accumulated in liver and spleen.Moreover,in vivo toxicity assessment demonstrates that LaF3:Nd^3+NRs feature low biotoxicity and good biocompatibility in living animals.Therefore,the NIR-Ⅱemitting hexagonal phase LaF3 NRs with controlled size are promising probes for optical bioimaging.Fluorescent imaging in the second near-infrared（NIR-Ⅱ, 1000-1700 nm） region has attracted enormous research interest due to its advantages of unprecedentedly improved imaging sensitivity and spatial resolution. Herein, high quality NIR-Ⅱ emissive LaF3:Nd3+ nanorods（NRs） with hexagonal phase structure and controlled size were synthesized by a hydrothermal method. And the Nd3+ doping induced NIRⅡ luminescent intensity evolution was studied, In vivo NIR-Ⅱ bioimaging and real-time tracking reveal that these LaF3:Nd3+ NRs are mainly accumulated in liver and spleen. Moreover, in vivo toxicity assessment demonstrates that LaF3:Nd3+ NRs feature low biotoxicity and good biocompatibility in living animals. Therefore, the NIR-Ⅱ emitting hexagonal phase LaF3 NRs with controlled size are promising probes for optical bioimaging.

关 键 词：NIR-Ⅱimaging Real-time tracking Downshifting luminescence Rare earths 

分 类 号：TF[冶金工程]