夫西地酸钠和万古霉素用于ICU病房耐甲氧西林金黄色葡萄球菌患者的疗效比较  

Efficacy Comparison of Sodium Fusidate and Vancomycin to Treat Patients with Methicillin-resistant Staphylococcus Aureus in ICU Ward

作　　者：张成汉 ZHANG Cheng-han(Intensive Care Unit,Dashiqiao Central Hospital,Dashiqiao 115100,Liaoning,China)

机构地区：[1]大石桥市中心医院重症监护病房

出　　处：《医学信息》2019年第18期149-150,共2页Journal of Medical Information

摘　　要：目的对比夫西地酸钠和万古霉素用于ICU病房耐甲氧西林金黄色葡萄球菌(MRSA)患者中的临床效果。方法选取我院2018年3月~12月收治的ICU病房MRSA患者42例,随机分为参照组和研究组,各21例。参照组给予万古霉素治疗,研究组给予夫西地酸钠治疗,比较两组患者的治疗效果及细菌清除率。结果参照组与研究组的治疗总有效率分别为90.48%、85.71%,差异无统计学意义(P>0.05)。参照组与研究组的细菌清除分别为95.24%、90.48%,差异无统计学意义(P>0.05)。结论应用夫西地酸钠对ICU病房MRSA患者进行治疗,获得了与万古霉素治疗效果相当的结果,两者细菌清除率也比较接近,因此对此类患者治疗过程中可应用夫西地酸钠作为替代药物。Objective To compare the clinical effects of sodium fusidate and vancomycin in patients with methicillin-resistant Staphylococcus aureus(MRSA)in the ICU ward.Methods 42 patients with ICU wards MRSA admitted to our hospital from March to December 2018 were randomly divided into reference group and study group,21 cases each.The reference group was treated with vancomycin,and the study group was treated with sodium fusidate.The treatment effect and bacterial clearance rate of the two groups were compared.Results The total effective rate of the reference group and the study group was 90.48%and 85.71%,respectively,the difference was not statistically significant(P>0.05).The bacterial clearance of the reference group and the study group were 95.24%and 90.48%,respectively,the difference was not statistically significant(P>0.05).Conclusion The treatment of MRSA patients in ICU ward with sodium fusidate has achieved comparable results with vancomycin.The bacterial clearance rate is similar.Therefore,fusidic acid can be applied to the treatment of such patients.Sodium is used as an alternative medicine.

关 键 词：夫西地酸钠 万古霉素 ICU病房 耐甲氧西林 金黄色葡萄球菌 

分 类 号：R459.7[医药卫生—急诊医学]