脐带血干细胞移植治疗非恶性血液病进展  

Umbilical cord blood stem cell transplantation for non-malignant hematological diseases

作　　者：王苹 翟晓文 Wang Ping;Zhai Xiaowen(Department of Hematology/oncology,Children's Hospital of Fudan University,Shanghai 201102,China)

机构地区：[1]复旦大学附属儿科医院血液科

出　　处：《中华细胞与干细胞杂志（电子版）》2019年第4期242-246,共5页Chinese Journal of Cell and Stem Cell（Electronic Edition）

摘　　要：异基因造血干细胞移植(allo-HSCT)是治愈多种非恶性病的有效方法。脐带血干细胞(UCB)具有免疫原性低、人类白细胞抗原不合耐受性好、移植物抗宿主反应发生率低以及获取相对快捷等特点,可作为非恶性血液疾病患者allo-HSCT的来源。本文简要综述脐血干细胞移植在原发性免疫缺陷病、遗传性骨髓衰竭、遗传代谢病以及自身免疫性疾病等非恶性血液疾病的治疗效果。Allogeneic hematopoietic stem cell transplantation(allo-HSCT)is an effective method to cure non-malignant hematological diseases.Umbilical cord blood stem cells(UCB)are characterized by weak immunogenicity,good tolerance human leukocyte antigen(HLA)mismatch,low incidence of graft-versus-host disease and relatively fast availability.UCB can be used as the graft of allo-HSCT for patients with non-malignant hematological diseases.This article reviews the efficacy of the umbilical cord blood stem cell transplantation(UCBT)in patients with primary immunodeficiency,hereditary bone marrow failure,hereditary metabolic diseases and autoimmune diseases.

关 键 词：脐带血 造血干细胞 移植 非恶性疾病 

分 类 号：R55[医药卫生—血液循环系统疾病]