β2微球蛋白与透析相关淀粉样变  

β2 microglobulin and dialysis-related amyloidosis

作　　者：姚英[1] 章友康[2] Yao Ying;Zhang Youkang(Department of Nephrology, Fuxing Hospital, Capital Medical University, Beijing 100038, China;Department of Nephrology, Peking University First Hospital, Peking University Institute of Nephrology, Beijing 100034, China)

机构地区：[1]首都医科大学附属复兴医院肾内科,100038 [2]北京大学第一医院肾内科,北京大学肾脏病研究所,100034

出　　处：《中华肾病研究电子杂志》2019年第3期128-131,共4页Chinese Journal of Kidney Disease Investigation（Electronic Edition）

基　　金：首都医科大学基础临床合作研究基金(16JL760)

摘　　要：β2微球蛋白(β2M)是典型的中分子尿毒症毒素,是透析相关淀粉样变的前体蛋白。透析相关淀粉样变是终末期肾脏病患者的一种严重并发症,主要表现为骨关节病变,如腕管综合征、骨囊肿、骨关节病、破坏性脊柱关节病等,晚期也可出现其他系统受累。本文就透析相关淀粉样变的发病机制、临床表现、诊断方法和防治等方面的研究进展进行了综述。β2 microglobulin(β2M) is a typical mid-molecular uremic toxin,and is a precursor protein for dialysis-related amyloidosis. Dialysis-related amyloidosis is a serious complication of patients with end-stage renal disease,mainly manifests as bone and joint lesions such as carpal tunnel syndrome,bone cyst,osteoarthrosis,destructive spondyloarthropathy,etc,and other organs systems may also be involved in the late stage. This article reviewed the research progress in the pathogenesis,clinical manifestations,diagnostic methods,and treatment and prevention of dialysis-related amyloidosis.

关 键 词：Β2微球蛋白 透析相关淀粉样变 

分 类 号：R692.5[医药卫生—泌尿科学]