线粒体乙醛脱氢酶2的心脏保护作用机制及靶向治疗的前景  

Mechanism of Mitochondrial Acetaldehyde Dehydrogenase-2 in Cardiac Protection and Prospect of ALDH2-Targeted Therapy

作　　者：张玄子 易春秀 赵雅静[1] ZHANG Xuanzi;YI Chunxiu;ZHAO Yajing.(Department of Cardiology,the Second Affiliated Hospital of Kunming MedicalUniversity,Kunming 650101,China)

机构地区：[1]昆明医科大学第二附属医院心内科

出　　处：《医学综述》2019年第17期3376-3381,共6页Medical Recapitulate

基　　金：云南省教育厅科学研究基金项目(2015Z078)

摘　　要：心血管疾病是人类死亡的重要原因之一,不同个体心血管疾病患病率及预后不同可能与遗传变异相关,乙醛脱氢酶2(ALDH2)rs671的多态性(rs671,G→A突变)与各种心血管疾病如心肌缺血和(或)再灌注损伤、高血压带来的高负荷、饮酒、糖尿病以及心力衰竭有密切的关系,ALDH2在各种心血管疾病中可能通过醛的解毒、抑制内质网应激、调节自噬、保护线粒体和遗传调控等不同途径和方式参与心脏保护作用。因此,靶向ALDH2治疗在心脏保护的临床应用中有重要的前景。Cardiovascular disease is one of the major causes of human death,and the difference of prevalence and prognosis of different individuals may be associated with genetic variation.Acetaldehyde dehydrogenase-2(ALDH2)rs671 polymorphism(rs671,G→A mutation)is proven to be closely related to various cardiovascular diseases such as myocardial ischemia and/or reperfusion injury,highhigh load of hypertension,drinking alcohol,diabetes and heart failure.ALDH2 is involved in cardiac protection by different ways or methods,such as aldehyde detoxification,endoplasmic reticulum stress,autophagy regulation,protection of mitochondriad and genetic regulation.Therefore,ALDH2-targeted therapy has a great prospect in the clinical application for heart protection.

关 键 词：心血管疾病 乙醛脱氢酶2 多态性 心脏保护 靶向治疗 

分 类 号：R34[医药卫生—基础医学]