芪苈强心胶囊联合比索洛尔治疗冠心病心力衰竭的疗效及对患者血流动力学的影响  

Clinical efficacy of Qiliqiangxin capsule combined with bisoprolol in the treatment of coronary heart disease with heart failure and its effect on hemodynamics

作　　者：董昕[1] 李建伟[1] 杨朋康 DONG Xin;LI Jian-wei;YANG Peng-kang(Department of Cardiology,the Fourth Hospital of Xi'an City,Xi'an 710004,Shaanxi,CHINA;Department of Cardiology,the First Hospital of Xi'an City,Xi'an 710002,Shaanxi,CHINA)

机构地区：[1]西安市第四医院心内科,陕西西安710004 [2]西安市第一医院心内科,陕西西安710002

出　　处：《海南医学》2019年第17期2185-2187,共3页Hainan Medical Journal

摘　　要：目的观察芪苈强心胶囊联合比索洛尔治疗冠心病心力衰竭的疗效及对患者血流动力学的影响。方法将西安市第四医院心内科2017年1月至2018年8月收治的132例冠心病心力衰竭患者作为研究对象,采用随机数表法分为观察组和对照组,每组66例。观察组患者应用芪苈强心胶囊及比索洛尔联合治疗,对照组单独采用芪苈强心胶囊口服治疗,两组均连续治疗3个月。观察两组患者治疗前后的临床指标(6 min步行最大距离、脑钠肽)及血流动力学指标[血压、心率、左室射血分数(LVEF)、每搏输出量(SV)、心脏指数(CI)和心输出量(CO)]的变化;比较两组患者的治疗效果。结果观察组患者的治疗总有效率为90.91%,明显高于对照组的72.73%,差异有统计学意义(P<0.05);治疗后,两组患者的心率及脑钠肽水平均明显低于治疗前,而LVEF、SV、CI、CO则明显高于治疗前,差异均有显著统计学意义(P<0.01);观察组患者治疗后的心率为(72.46±7.53)次/min、脑钠肽水平为(1 369.56±537.82) ng/mL,均明显低于对照组的(77.31±7.56)次/min、(2 364.56±643.86) ng/mL,差异均有统计学意义(P<0.05);治疗后的6 min步行最大距离[(376.59±63.64) m vs (336.63±62.56) m]、LVEF [(64.62±7.13)%vs (59.34±5.41)%]、SV [(45.31±6.82) mL vs (39.14±5.89) mL]、CI [(3.23±1.09) L·min^-1·m^-2vs (2.27±0.76) L·min^-1·m^-2]及CO [(4.65±1.48) L/min vs (3.94±1.32) L/min]比较,观察组均明显多于对照组,差异均有统计学意义(P<0.05)。结论芪苈强心胶囊联合比索洛尔治疗冠心病心力衰竭的疗效显著,其可明显改善患者的血流动力学,降低心率及脑钠肽水平,且不会增加不良反应,具有临床应用价值。Objective To analyze the clinical effect of Qiliqiangxin capsule combined with bisoprolol in patients with coronary heart disease and heart failure and to investigate its effect on hemodynamics. Methods A total of 132 patients with coronary heart disease and heart failure treated in Department of Cardiology, the Fourth Hospital of Xi'an City from January 2017 to August 2018 were selected as the subjects of study. The patients were randomly divided into an observation group (n=66) and a control group (n=66) according to random number table, which were treated with Qiliqiangxin capsule combined with bisoprolol and single Qiliqiangxin capsule, respectively, for 3 months. The changes of the clinical indexes (6 min walking distance, brain natriuretic peptide) and hemodynamic indexes (blood pressure, heart rate, left ventricular ejection fraction [LVEF], stroke volume [SV], cardiac index [CI] and cardiac output [CO]) were observed before and after treatment, and the therapeutic effects of the two groups were compared. Results The total effective rate of the treatment in the observation group was 90.91%, which was significantly higher than 72.73% of the control group (P<0.05). After treatment, the heart rate, and brain natriuretic peptide levels in the two groups were significantly lower than those before treatment, while the LVEF, SV, CI, CO of the two groups were significantly higher than those before treatment (all P<0.01). The heart rate of the observation group was (72.46±7.53) beats/min, and brain natriuretic peptide level was (1 369.56±537.82) ng/mL, which were significantly lower than (77.31±7.56) times/min,(2 364.56±643.86) ng/mL of the control group (P<0.05). The observation group was also significantly more or higher than the control group in 6 min walking distance, LVEF, SV, CI, and CO after treatment (all P<0.05):(376.59±63.64) m vs (336.63±62.56) m,(64.62± 7.13)% vs (59.34±5.41)%,(45.31±6.82) mL vs (39.14±5.89) mL,(3.23±1.09) L·min^-1·m^-2 vs (2.27±0.76) L·min^-1·m^-2,(4.65±1.48) L/min vs

关 键 词：比索洛尔 芪苈强心胶囊 动脉粥样硬化 冠心病 心力衰竭 血流动力学 心功能 

分 类 号：R541.4[医药卫生—心血管疾病]