维生素D缺乏与妊娠期糖尿病及其母婴结局研究进展  

Vitamin D Deficiency,Gestational Diabetes Mellitus and Its Maternal and Fetal Outcomes

作　　者：周芳 厉平[1] ZHOU Fang;LI Ping(Department of Endocrinology,Shengjing Hospital of China Medical University,Shenyang 110022,China)

机构地区：[1]中国医科大学附属盛京医院内分泌科

出　　处：《中国全科医学》2019年第29期3533-3538,共6页Chinese General Practice

摘　　要：妊娠期糖尿病可导致母婴不良结局,近年来我国妊娠期糖尿病发病率不断上升。维生素D可改善胰岛素敏感性和葡萄糖耐量,多项研究表明维生素D缺乏与妊娠期糖尿病风险增加有关,但是仍有部分研究结果与此相反。且目前研究多为观察性研究,随机对照试验数据有限,补充维生素D能否预防妊娠期糖尿病发生尚无定论。本文系统回顾了维生素D缺乏与妊娠期糖尿病发生风险的关系,同时就补充维生素D能否预防妊娠期糖尿病、改善妊娠期糖尿病患者糖脂代谢状态和母婴结局做一综述。Gestational diabetes can lead to adverse outcomes in mothers and babies.In recent years,the incidence of gestational diabetes in China has been rising.Vitamin D can improve insulin sensitivity and glucose tolerance,and many studies have shown that vitamin D deficiency is associated with an increased risk of gestational diabetes,while some studies have the opposite conclusion.In addition,most of the studies are observational studies,with few randomized controlled trials. Whether vitamin D supplementation can prevent gestational diabetes is still inconclusive.This article systematically reviewed the risk of vitamin D deficiency and gestational diabetes,and reviewed whether vitamin D supplementation can prevent gestational diabetes,improve glycolipid metabolism and maternal and fetal outcomes in patients with gestational diabetes.

关 键 词：维生素D缺乏 糖尿病 妊娠 胰岛素抵抗 婴儿 新生 综述 

分 类 号：R591.44[医药卫生—内科学] R714.256[医药卫生—临床医学]