DNA倍体定量分析法对改善宫颈癌筛查覆盖率的作用研究  

Application of DNA ploidy quantitative analysis in cervical cancer screening to improve screening coverage

作　　者：陈赞兵 CHEN Zanbing(Department of Clinical Laboratory,Huangmei Women And Child Health Care Hospital,Huanggang,Hubei 435500,China)

机构地区：[1]湖北省黄冈市黄梅县妇幼保健院检验科

出　　处：《检验医学与临床》2019年第17期2487-2489,共3页Laboratory Medicine and Clinic

摘　　要：目的探讨宫颈癌筛查中应用DNA倍体定量分析法对改善筛查覆盖率的作用。方法收集2017年12月至2018年12月该院收治的128例已婚妇女作为研究对象,均进行宫颈癌筛查,利用DNA倍体定量分析法进行测定,同时行液基薄层细胞学(TCT)检测。TCT与DNA倍体定量分析法测定结果均为阳性者,进一步予以病理学检查。结果128例已婚妇女中,有36例异倍体细胞患者(28.13%),其中1~2个异倍体细胞者20例,3个及以上者16例。阴道镜检,浸润癌、原位癌、CINⅡ及以上病变者17例。宫颈癌、CIN多发于30~45岁人群,不同年龄段的病变程度各有不同。与TCT比较,DNA倍体定量分析法的癌前病变的检出率以及对宫颈癌的检出率均比较高(P<0.05)。结论临床筛查宫颈癌患者过程中,DNA倍体定量分析法十分有效,能够进一步改善筛查覆盖率,促使临床尽早规范诊治宫颈病变,从而降低宫颈癌患者的发病率、病死率。Objective To explore the effect of DNA ploidy quantitative analysis on improving screening coverage in cervical cancer screening.Methods A total of 128 married women admitted to our hospital from December 2017 to December 2018 were screened for cervical cancer,determined by DNA ploidy quantitative analysis,and detected by TCT(liquid-based thin layer cytology).The results of TCT and DNA ploidy quantitative analysis were positive,and further pathological examination was performed.Results Among 128 married women,36 cases were aneuploid,the percentage was 28.13%.Among them,there were 20 cases with 1-2 aneuploidy cells and 16 cases with 3 or more aneuploidy cells.Colposcopic examination showed that 17 cases had infiltrating cancer,carcinoma in situ and CINⅡor above.Cervical cancer and CIN mostly occur in 30-45 years old group,and the degree of lesion varies in different age groups.Compared with TCT,the detection rate of DNA ploidy quantitative analysis before carcinogenesis and cervical cancer were higher(P<0.05).Conclusion DNA ploidy quantitative analysis is very effective in clinical screening of cervical cancer patients.It can further improve the screening coverage,prompt clinical early standardization of diagnosis and treatment of cervical lesions,thereby reducing the incidence and mortality of cervical cancer patients.

关 键 词：宫颈癌 DNA倍体定量分析法 筛查覆盖率 改善作用 

分 类 号：R446.1[医药卫生—诊断学]