抑郁症的线粒体能量代谢障碍刍议  

Mitochondrial energy metabolism disorder in depression

作　　者：于姚 郭蓉娟 史华伟 袁清洁 李阳[1] Yu Yao;Guo Rongjuan;Shi Huawei;Yuan Qingjie;Li Yang(Beijing University of Chinese Medicine,Beijing 100029,China;Dongfang Hospital,Beijing University of Chinese Medicine,Beijing 100078,China;Dongzhimen Hospital,Beijing University of Chinese Medicine,Beijing 100700,China;Beijing Hospital of Integrated Traditional Chinese and Western Medicine,Beijing 100039,China)

机构地区：[1]北京中医药大学,北京100029 [2]北京中医药大学东方医院 [3]北京中医药大学东直门医院 [4]北京市中西医结合医院

出　　处：《北京中医药大学学报》2019年第7期602-606,共5页Journal of Beijing University of Traditional Chinese Medicine

基　　金：国家自然科学基金资助项目(No.81072717,No.81273624,No.81573843,No.81874422)~~

摘　　要：抑郁症是严重危害人类健康的重大疾病,其发病机制尚不明确,现有的单胺假说难以解释抑郁症的多系统复杂症状,药物治疗也遇到瓶颈。大量证据表明线粒体能量代谢障碍参与了抑郁症发生发展的过程,有可能成为抑郁症防治的新靶标。本文提出抑郁症的线粒体能量代谢障碍假说,认为线粒体能量代谢障碍是抑郁症发生发展的重要病理机制,是精神症状加重、躯体症状泛化的关键病理环节,而改善线粒体能量代谢障碍可有效缓解抑郁症的精神与躯体症状。这一假说可为抑郁症研究提供新思路。Depression is a major disease which can cause serious damage to human health. Its pathogenesis is still unclear;and the existing monoamine hypothesis failed to adequately explain its multi-system complex symptoms. Moreover, drug therapy also encountered bottlenecks. Many evidences have indicated that mitochondrial energy metabolism disorder is closely related to the occurrence and development of depression, which may become a new target for depression drug develop ment. In this paper, we put forward the hypothesis of mitochondrial energy metabolism disorder in depression. Our hypothesis is that mitochondrial energy metabolism disorder is an important pathological mechanism for the occurrence and development of depression, and a key pathological phenomenon manifesting as the aggravation of mental symptoms and the generalization of physical symptoms. Therefore, improving the disorder can effectively alleviate the mental and physical symptoms of depression. This hypothesis can provide new ideas for the study of depression.

关 键 词：抑郁症 线粒体 能量代谢障碍 假说 

分 类 号：R277.749[医药卫生—中医学]