脑肠轴传输中的胃肠肽类激素  

Gastrointestinal peptide hormones associated with brain-intestinal axis

作　　者：刘娅薇 惠华英[1] 谭周进[1] Ya-Wei Liu;Hua-Ying Hui;Zhou-Jin Tan(Hu’nan University of Chinese Medicine,Changsha 410208,Hu’nan Province,China)

机构地区：[1]湖南中医药大学

出　　处：《世界华人消化杂志》2019年第16期1007-1012,共6页World Chinese Journal of Digestology

基　　金：湖南省教育厅项目,No.13B082~~

摘　　要：脑肠轴是消化道和中枢神经系统的生物化学信号,控制着肠和脑之间的双向信息交流系统,由免疫、迷走神经和神经内分泌途径构成.脑肠肽(brain-gutpeptide,BGP)是脑肠轴中调节胃肠功能、参与调节胃肠生理活动一种小分子多肽,在脑肠互动中调控胃肠道疾病发挥重要作用.而胃肠肽类激素作为BGP的分子基础,不仅作用于胃肠道功能运动,还通过炎症反应、免疫反应等影响全身的代谢、心血管功能甚至人类行为.本文对胃肠肽类激素与脑肠轴之间的相互作用机制作一综述,期望能对相关疾病治疗提供线索及思路.The brain-intestinal axis is the interaction between biochemical signals of the digestive tract and the central nervous system,controls the two-way information exchange between the intestine and brain,and is composed of immune,vagus nerve,and neuroendocrine pathways.Brain-gut peptide(BGP)is a small molecule polypeptide that regulates gastrointestinal function and participates in regulating gastrointestinal physiological activities in the brain-intestinal axis,and is involved in the pathogenesis of gastrointestinal diseases by regulating brain-intestinal interaction.As a molecular basis of BGP,gastrointestinal peptide hormones not only affect the functional movement of the gastrointestinal tract,but also regulate the metabolism,cardiovascular function,and even human behavior of the whole body through inflammatory reactions and immune responses.This article reviews the interaction between gastrointestinal peptide hormones and the brain-intestinal axis,with an aim to provide clues and ideas for the treatment of related diseases.

关 键 词：胃肠肽激素 脑肠肽 脑肠轴 

分 类 号：R33[医药卫生—人体生理学]