健脾消瘿汤对脾气亏虚型桥本甲状腺炎患者的临床疗效  

Clinical effects of Jianpi Xiaoying Decoction on patients with Hashimoto’s thyroiditis due to Spleen-Qi Deficiency

作　　者：陈秋野[1] 周兰 马燕云[1] 唐红[1] CHEN Qiu-ye;ZHOU lan;MA Yan-yun;TANG Hong(Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 200032,China;Shanghai Yangpu District Hospital of Traditional Chinese Medicine,Shanghai 200090,China)

机构地区：[1]上海中医药大学附属龙华医院,上海200032 [2]上海市杨浦区中医医院,上海200090

出　　处：《中成药》2019年第9期2102-2106,共5页Chinese Traditional Patent Medicine

基　　金：上海市“科技创新行动计划”临床医学领域项目(17401970200);上海中医药大学预算内项目(自然科学类)(2016YSN38)

摘　　要：目的观察健脾消瘿汤对脾气亏虚型桥本甲状腺炎患者的临床疗效。方法 80例患者随机为观察组和对照组,每组40例,观察组给予健脾消瘿汤,对照组给予硒酵母,疗程12周。然后,检测临床疗效、甲状腺抗体(TGAb、TPOAb)、免疫因子(IFN-γ、IL-4、IL-4/IFN-γ)、杨氏模量值、中医证候评分变化。结果观察组甲状腺抗体、IFN-γ水平、杨氏模量值、中医证候评分显著低于对照组(P<0.05),IL-4/IFN-γ、总有效率显著升高(P<0.05,P<0.01)。2组IL-4水平无显著差异(P>0.05)。结论健脾消瘿汤可有效降低脾气亏虚型桥本甲状腺炎患者抗体滴度,改善甲状腺弹性,临床疗效优于硒酵母,其机制可能是调节Th1/Th2免疫失衡,减轻炎症反应。AIM To observe the clinical effects of Jianpi Xiaoying Decoction on patients with Hashimoto’s thyroiditis due to Spleen-Qi Deficiency.METHODS Eighty patients were randomly divided into observation group(40 cases) for 12-week administration of Jianpi Xiaoying Decoction, and control group(40 cases) for 12-week administration of selenium yeast. Subsequently, the changes in clinical efficacy, thyroid antibodies(TGAb, TPOAb), immune factors(IFN-γ, IL-4, IL-4/IFN-γ), Young’s modulus value and TCM syndrome score were detected. RESULTS The observation group demonstrated significantly lower thyroid antibodies, IFN-γ level, Young’s modulus value and TCM syndrome score than the control group(P<0.05), along with markedly higher IL-4/IFN-γ and total effective rate(P<0.05, P<0.01). No obvious difference in IL-4 level was found in the two groups(P>0.05). CONCLUSION For the patients with Hashimoto’s thyroiditis due to Spleen-Qi Deficiency, Jianpi Xiaoying Decoction can effectively reduce antibody titers and thyroid elasticity, exhibiting better clinical efficacy than Selenium Yeast, whose mechanisms may contribute to the adjustment of Th1/Th2 immunity imbalance and alleviation of inflammatory reactions.

关 键 词：健脾消瘿汤 桥本甲状腺炎 脾气亏虚型 

分 类 号：R287[医药卫生—中药学]