高精度经颅直流电刺激对精神分裂症患者视空间工作记忆的影响  

Effect of high-definition transcranial direct current stimulation on visual spatial working memory in patients with schizophrenia

作　　者：许飞飞 何孔亮[2] 王璐[3] 陈新贵[3] 吴小玲 肖桂贤 汪凯[3] Xu Feifei;He Kongliang;Wang Lu;Chen Xingui;Wu Xiaoling;Xiao Guixian;Wang Kai(Anhui Psychiatric Center,Anhui Medical University,Hefei 230022,China;Anhui Mental Health Center,Hefei 230022,China;Department of Neurology,the First Affiliated Hospital of Anhui Medical University,Hefei 230022,China)

机构地区：[1]安徽医科大学安徽省精神医学中心,合肥230022 [2]安徽省精神卫生中心,合肥230022 [3]安徽医科大学第一附属医院神经内科,合肥230022

出　　处：《中华行为医学与脑科学杂志》2019年第8期699-704,共6页Chinese Journal of Behavioral Medicine and Brain Science

基　　金：国家自然科学基金项目(31571149,91432301,81803103,81171273);合肥市卫计委应用医学研究项目(hwk2018zc005).

摘　　要：目的探讨高精度经颅直流电刺激对精神分裂症患者视空间工作记忆的影响.方法入组66例精神分裂症患者,采用随机,双盲,安慰剂对照的研究设计,按随机数字表法将被试随机分为真刺激组33例与安慰剂对照组33例,每个患者仅接受一次刺激,利用高精度经颅直流电刺激患者左侧背外侧前额叶,真刺激组采用1.5mA的电流刺激20min,对照组采用伪刺激,仅刺激开始和结束的30s内有电流通过.两组患者在刺激前均完成神经心理背景测试以及n-back任务;5d以后进行一次刺激,刺激结束后两组患者再次完成n-back任务,对比分析观察刺激前后n-back任务成绩的变化,以此来反映工作记忆的变化.结果刺激前后在3-back任务的反应正确率上,与对照组成绩[(0.32±0.21),(0.32±0.22)]相比,真刺激组[(0.28±0.19),(0.35±0.21)],差异有统计学意义(F=5.298,P=0.025).结论高精度经颅直流电刺激刺激左背外侧前额叶皮层能提高患者视空间工作记忆功能,未来该技术可应用于精神分裂症患者记忆障碍的认知促进.Objective To investigate the effect of high-definition transcranial direct current stimulation on visual spatial working memory in patients with schizophrenia. Methods Sixty-six patients with schizophrenia were enrolled in a randomized, double-blind, placebo-controlled study. The subjects were randomized into a true stimulation group of 33 patients and a placebo control group of 33 patients, each patient only received one stimulation. After receiving a stimulus, the left dorsolateral prefrontal lobe was stimulated by high-precision transcranial direct current. The true stimulation group was stimulated with a current of 1.5 mA for 20 min. The control group used pseudo-stimulation, and only the current was passed within 30 s of the beginning and the end of the stimulation. Both groups completed the neuropsychological background test and the n-back task before stimulation, and the stimulation was performed after five days. After the stimulation, the two groups completed the n-back task again, and compared the Changes in grades to reflect changes in working memory before and after the pseudo-stimulation. Results Before the stimulation, the response rate of the 3-back task was compared with that of the control group ((0.32±0.21),(0.32±0.22)), the true stimulation group ((0.28±0.19),(0.35±0.21)), and the difference was statistically significant (F=5.298, P=0.025). Conclusion Using high-definition transcranial direct current stimulation to stimulate the left dorsolateral prefrontal cortex using can improve the visual memory function of patients. In the future, this technique can be applied to the cognitive promotion of memory impairment in patients with schizophrenia.

关 键 词：高精度经颅直流电刺激 工作记忆 精神分裂症 

分 类 号：R749.3[医药卫生—神经病学与精神病学]