老年骨质疏松性骨折病人发生心脏疾病的相关因素研究  

Risk factors of heart disease in elderly patients with osteoporosis fracture

作　　者：李传静 乐静[1] 刘爱林[1] 赵涛[1] 李睿[1] LI Chuan-jing;LE Jing;LIU Ai-lin;ZHAO Tao;LI Rui(Department of Endocrinology, Xiaogan Hospital,Wuhan University of Science and Technology,Wuhan 432100,China)

机构地区：[1]武汉科技大学附属孝感医院内分泌科

出　　处：《实用老年医学》2019年第9期888-891,共4页Practical Geriatrics

摘　　要：目的研究老年骨质疏松性骨折(OF)病人发生心脏疾病的危险因素,为制定预防性措施提供参考。方法采用回顾性分析,收集我院骨科2016年1月至2018年6月收治的老年骨质疏松性骨折病人227例,根据是否发生心脏疾病分为心脏疾病组(n=69)与对照组(n=158),收集病人基本资料、主要生化检测指标、用药情况等,并进行单因素和多因素分析。结果心脏疾病组甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)水平明显高于对照组,差异有统计学意义(P<0.05或P<0.01)。2组年龄、性别、使用雌激素、使用钙剂、维生素D、合并糖尿病、合并高血压以及吸烟史差异均有统计学意义(P<0.05或P<0.01)。多因素Logistic回归分析显示,女性、吸烟、使用雌激素、血脂水平高、合并高血压是老年OF病人发生心脏疾病的危险因素,使用钙剂和维生素D是保护因素。结论老年骨质疏松性骨折病人发生心脏疾病与性别、用药、高血压、高脂血症等因素密切相关,在治疗时应根据情况采取积极、系统的全身性预防措施。Objective To investigate the risk factors of heart disease in the elderly patients with osteoporosis fracture (OF). Methods A retrospective analysis was performed to collect 227 cases of elderly patients with OF in the Department of Orthopedics of our hospital from January 2016 to June 2018. The patients were divided into the heart disease group ( n = 69) and the control group ( n = 158) according to the occurrence of cardiac diseases. Single factor analysis and Logistic regression analysis were performed to identify the risk factors of cardiac disease. Results The levels of triglyceride(TG) and low destiny lipoprotein cholestrol-C(LDL-C) in the heart disease group were significantly higher than those in the control group( P < 0.05 or P < 0.01). Univariate analysis showed that age, gender, the use of estrogen, calcium, vitamin D, diabetes mellitus, hypertension and smoking were risk factors for heart disease ( P < 0.05 or P < 0.01). Multivariate Logistic regression analysis showed that female, smoking, the use of estrogen, high levels of TG and LDL-C, and combination of hypertension were risk factors for heart disease in the elderly patients with OF. And the use of calcium and vitamin D were protective factors. Conclusions The occurrence of heart disease in the elderly patients with OF is closely related to gender, medication, hypertension, hyperlipidemia and smoking.

关 键 词：老年人 骨质疏松性骨折 心脏疾病 危险因素 

分 类 号：R681[医药卫生—骨科学]