六味地黄丸联合匹多莫德治疗小儿反复呼吸道感染的疗效观察  

Effect of Liuwei Dihuang pills associated with pidotimod in treating the recurrent respiratory tract infection in children

作　　者：吴杰妍 WU Jie-yan(Department of Pediatrics,Third affiliated hospital of Guangzhouuniversity of traditional Chinese medicine,Guangzhou 510380,Guangdong China)

机构地区：[1]广州中医药大学第三附属医院

出　　处：《内蒙古中医药》2019年第8期7-9,共3页Inner Mongolia Journal of Traditional Chinese Medicine

基　　金：广东省中医药管理局项目(《六味地黄丸合匹多莫德治疗小儿反复呼吸道感染临床观察》,编号:20172084)

摘　　要：目的:研究六味地黄丸(LDP)联合匹多莫德治疗小儿反复呼吸道感染(RRTI)的疗效作用及其对免疫球蛋白IgA、IgG、IgM、CD4^+、CD8^+、CD4^+/CD8^+比值的影响。方法:选取2015年2月~2016年2月在广州中医药大学第三附属医院儿科治疗的RRTI患儿60例,以随机数表法分为对照组与观察组,每组30例。两组急性发作期均给予抗感染及对症处理等临床路径治疗。对照组缓解期加用匹多莫德口服,而观察组在对照组基础上加用六味地黄丸治疗。两组均连续治疗10周,治疗后6个月内进行随访。观察两组治疗后的症状和体征改善情况;观察两组咳嗽复发次数;观察两组治疗前后慢性咳嗽影响量表(CCIQ)及咳嗽症状评分改善情况;检测血清IgG、IgA、IgM及CD4^+、CD8^+、CD4^+/CD8^+比值的水平。结果:观察组总有效率(90.00%)明显高于对照组(66.67%),差异有统计学意义(P<0.05)。观察组复发次数明显少于对照组,差异有统计学意义(P<0.05)。观察组治疗后CCIQ及咳嗽症状评分均明显低于对照组,差异有统计学意义(P<0.05)。治疗后观察组IgG、IgA、IgM水平均高于对照组,差异有统计学意义(P<0.05)。治疗后观察组CD4^+、CD8^+、CD4^+/CD8^+比值均高于对照组,差异有统计学意义(P<0.05)。结论:六味地黄丸联合匹多莫德可减少患儿咳嗽复发次数及改善临床症状,其作用主要与提高IgA、IgM、IgG及CD4^+/CD8^+水平有关。Objective:To investigate the effect of Liuwei Dihuang Pills(LDP)and pidotimod in treating the recurrent respiratory tract infection(RRTI)in children and its effects on the immunoglobulin IgA,IgG,IgM and CD4^+,CD8^+and CD4^+/CD8^+.Methods:60 patients with RRTI from the third affiliated hospital of Guangzhou university of traditional Chinese medicine during February 2015 to February 2016 were collected.There were 30 patients in both observation and control group,divided by the random number table.Patients in each group were treated with the conventional therapy of clinical pathway like anti-infection and symptomatic treatment in the acute stage.Then in the remittent stage,patients in control group were given the pidotimod,while those in observation group were treated additionally with LDP.All patients were treated with 10 weeks and there were 6 months follow-up.The improvement of signs and symptoms and the recurrent times were observed.The chronic cough impact scale(CCIQ)and cough symptom score were collected.The serum concentrations of IgG,IgA,IgM,CD4^+,CD8^+and CD4^+/CD8^+were tested.Results:The total effective rate of observation group was obviously higher than the control one(90.00%vs 66.67%)and there was the difference(P<0.05).The recurrent times of observation group was less than the control one and there was the difference(P<0.05).After medication,CCIQ and cough symptom scores in observation group were less than the control group,and there were the differences(P<0.05).The serum concentrations of IgG,IgA and IgM in the observation group were more than the control group and there were the differences(P<0.05).Indeed,the serum concentrations of CD4^+,CD8^+and CD4^+/CD8^+in the observation group were also more than the control group and there were the differences(P<0.05).Conclusion:LDP associated with pidotimod could reduce the recurrence and improve the manifestations,which was related to the improvement of IgA,IgM,IgG and CD4^+/CD8^+.

关 键 词：六味地黄丸 匹多莫德 反复呼吸道感染 小儿 

分 类 号：R725.6[医药卫生—儿科]