两种治疗方案对支架内再狭窄患者冠脉造影效果及临床事件发生风险的影响  

Effects of two treatment regimens on coronary angiography and risk of clinical events in patients with in-stent restenosis

作　　者：余小妹 杨栋[1] 周莉[1] 陈宇凯[1] 王明伟[1] YU Xiaomei;YANG Dong;ZHOU Li;CHEN Yukai;WANG Mingwei(Department of Cardiology, Affiliated Hospital of Hangzhou Normal University, Hangzhou 310015, China)

机构地区：[1]杭州师范大学附属医院心内科

出　　处：《中国现代医生》2019年第23期15-18,共4页China Modern Doctor

基　　金：浙江省医药卫生科研基金项目(2017KY526)

摘　　要：目的探讨药物洗脱球囊和药物洗脱支架对支架内再狭窄患者冠脉造影效果及临床事件发生风险的影响。方法选取我院2015年1月~2016年12月收治支架内再狭窄患者共100例为研究对象,根据治疗方案差异随机分为A组(50例)和B组(50例),A组患者采用药物洗脱支架治疗,B组患者采用药物洗脱球囊方案治疗;比较两组患者术后随访晚期管腔丢失量、二次再狭窄率、Mehran再狭窄分型及临床事件发生率。结果两组患者晚期管腔丢失量比较,B组晚期管腔丢失量较A组更少(P<0.05),两组二次再狭窄率比较,差异无统计学意义(P>0.05);两组患者Mehran再狭窄分型情况比较,差异无统计学意义(P>0.05);两组患者临床事件发生率比较,差异无统计学意义(P>0.05)。结论药物洗脱球囊治疗支架内再狭窄总体疗效不逊于药物洗脱支架,具有临床应用价值。Objective To investigate the effects of drug-eluting balloon and drug-eluting stent on coronary angiography and risk of clinical events in patients with in-stent restenosis. Methods A total of 100 patients with in-stent restenosis were enrolled in our hospital from January 2015 to December 2016. They were randomly divided into group A (50 cases) and group B(50 cases) according to the treatment plan, and the group A was treated with eluting stents, the group B was treated with drug-eluting balloon. The late lumen loss, secondary restenosis rate, Mehran restenosis classification, and clinical event rate were compared between the two groups during the postoperative follow-up. Results The amount of late luminal loss in group B was significantly less than that in the group A(P<0.05). There was no significant difference in the rate of secondary restenosis between the two groups(P>0.05).There was no significant difference in the classification of Mehran restenosis between the two groups(P>0.05). There was no significant difference in the incidence of clinical events between the two groups(P>0.05). Conclusion The drug-eluting balloon is not inferior to the drug-eluting stent in the treatment of in-stent restenosis, and has clinical application value.

关 键 词：药物洗脱球囊 药物洗脱支架 支架内再狭窄 冠脉造影效果 临床事件 

分 类 号：R543[医药卫生—心血管疾病]