温度敏感型原位凝胶药物递送系统的研究进展  

Temperature-sensitive in situ gel delivery system:research advances

作　　者：宋亚 祁小乐[1] 沙康 曾佳 吴正红[1] SONG Ya;QI Xiao-le;SHA Kang;ZENG Jia;WU Zheng-hong(School of Pharmaceutical Science,China Pharmaceutical University,Nanjing 211198,China)

机构地区：[1]中国药科大学药学院

出　　处：《国际药学研究杂志》2019年第4期245-255,共11页Journal of International Pharmaceutical Research

基　　金：中国药科大学双一流国际药品注册创新团队(CPU2018GY40)

摘　　要：近年来,温度敏感型原位凝胶作为一种高亲和性的局部给药系统受到了越来越多的关注,其在室温条件下呈液态而方便给药,体温环境下可在用药部位发生相转变,形成局部药物储库,实现药物持续且缓慢释放。本文通过相关文献调研,对温敏凝胶材料的发展、胶凝机制、相关性质评价以及其在药物递送系统方面的应用进行综述。Recently,temperature-sensitive hydrogels have received more and more attention as a high-affinity topical drug de. livery system. The hydrogels show a liquid status at room temperature,which is convenient for injection administration. But they will undergo phase changes in the body temperature to form a local drug reservoir for sustained drug release.This paper reviews the research developments of different temperature- sensitive hydrogels materials,the gelation mechanism,relevant property evaluation and their application in drug delivery systems through relevant literature research.

关 键 词：温敏性 原位凝胶 胶凝机制 性质评价 药物递送系统 

分 类 号：R94[医药卫生—药剂学]