肠道菌群对动脉粥样硬化发病的影响及机制  

Effect of intestinal flora on the pathogonesis of atherosclerosis and its mechanism

作　　者：于佳琪 齐桂红 郭鹏[1] 吴崇明[1] YU Jia-qi;QI Gui-hong;GUO Peng;WU Chong-ming(Pharmacology and Toxicology Research Center,Institute of Medicinal Plant Development,Chinese Academy ofMedical Sciences,Peking Union Medical College,Beijing 100193,China)

机构地区：[1]中国医学科学院北京协和医学院药用植物研究所药理毒理中心

出　　处：《国际药学研究杂志》2019年第4期256-260,282,共6页Journal of International Pharmaceutical Research

基　　金：国家自然科学基金资助项目(81673663)

摘　　要：动脉粥样硬化是最常见的心血管系统疾病,以脂质和复合糖类在动脉内壁的异常聚集为特征,涉及一系列代谢和炎症反应。动脉粥样硬化的发病机制非常复杂,最近研究发现肠道菌群可通过对宿主代谢和炎症的调节影响动脉粥样硬化的进程,因此受到广泛关注。本文通过对近年来关于肠道菌群和动脉粥样硬化的关系研究进展进行回顾,系统介绍肠道菌群微生态对动脉粥样硬化发病的影响,探讨了肠道菌群调节动脉粥样硬化的潜在机制,益生菌的补给对动脉粥样硬化的治疗益处以及通过调节肠道菌群预防和延缓动脉粥样硬化的方法。Atherosclerosis,the most common cardiovascular disease characterized by abnormal accumulation of lipids and complex carbohydrate in the arterial wall,involves a series of metabolic and inflammatory reactions. The pathogenesis of atherosclero. sis is very complex. Recent studies have found that gut microbiota can influence the progress of atherosclerosis via regulating host metabolism and inflammation,which has attracted broad attention. In this paper,we review the recent research progress in the relation. ship between intestinal flora and atherosclerosis,systematically introduce the influence of intestinal microflora in the pathogenesis of atherosclerosis,and explore the underlying mechanisms by which intestinal flora regulates atherosclerosis,the therapeutic benefits of probiotic supplementation for atherosclerosis,and the prevention and delay of atherosclerosis by regulating intestinal flora.

关 键 词：肠道菌群 动脉粥样硬化 代谢产物 作用机制 

分 类 号：R96[医药卫生—药理学]