基于各向异性光吸收的线偏振光声成像  

Linearly Polarized Photoacoustic Imaging Based on Anisotropic Optical Absorption

作　　者：石玉娇 张振辉 Shi Yujiao;Zhang Zhenhui(Key Laboratory of Laser Life Science,Ministry of Education,Institute of Laser Life Science, College of Biophotonics, South China Normal University ,Guangzhou , Guangdong 510631, China)

机构地区：[1]华南师范大学生物光子学研究院激光生命科学研究所激光生命科学教育部重点实验室

出　　处：《中国激光》2019年第8期224-230,共7页Chinese Journal of Lasers

基　　金：国家自然科学基金青年科学基金(61805085);2017年度博士后创新人才支持计划(BX201700084);中国博士后面上项目(2018M630961);广东省自然科学基金博士科研启动项目(2018A030310519);广东省普通高校青年创新人才项目

摘　　要：为解决传统的光声成像技术通常将组织的吸收系数假定为无方向性的标量常数而忽略组织各向异性光吸收特性的问题,利用两束电矢量方向相互垂直的线偏振光作为光声成像的激发源,提出一种基于各向异性光吸收的线偏振光声成像技术;搭建线偏振光光声显微成像系统,并选取具有各向异性光吸收差异的材料作为样品,对所提技术的可行性进行实验验证;进一步对生物样品进行成像,演示所提技术对各向异性光吸收生物样本的成像能力。结果表明,所提技术易植入传统的光声显微成像系统中,拓展了传统光声成像的信息提取范围。In conventional photoacoustic(PA) imaging, the tissue absorption coefficient is usually considered to be a non-directional scalar constant, and its anisotropic optical absorption characteristics are ignored. Herein, we propose an anisotropic PA microscopy(A-PAM) technique that uses two linearly polarized light beams perpendicular to each other as the excitation source for PA imaging. Subsequently, we develop the A-PAM imaging system and verify the feasibility of the proposed method using phantoms that exhibit different forms of anisotropic optical absorption. Furthermore, we demonstrate the imaging ability of this method using biological samples that exhibit anisotropic absorption. Results show that the proposed method can be easily implanted into the conventional PAM imaging system, expanding the range of information extracted using conventional PA imaging.

关 键 词：生物光学 光声成像 线偏振光 各向异性 吸收差异 

分 类 号：O436[机械工程—光学工程]