血清补体C1q水平与代谢综合征的相关性研究  

Correlation of serum complement C1q level with metabolic syndrome

作　　者：唐浩能[1] 刘首娉 陈若虹[1] 付瑶阳 庄思琪 胡敏[1] 唐玲丽[1] Tang Haoneng;Liu Shoupin;Chen Ruohong;Fu Yaoyang;Zhuang Siqi;Hu Min;Tang Lingli(Department of Laboratory Medicine,the Second XiangYa Hospital,Central South University,Changsha 410011,China)

机构地区：[1]中南大学湘雅二医院检验科,长沙410011

出　　处：《中华检验医学杂志》2019年第8期657-661,共5页Chinese Journal of Laboratory Medicine

基　　金：国家自然科学基金(81600666).

摘　　要：目的分析代谢综合征(MS)患者血清补体C1q水平的变化,探讨MS患者血清补体C1q水平与体内糖、脂代谢指标的相关性.方法采用横断面研究,选取2017年7月至2018年6月在中南大学湘雅二医院就诊的患者及健康体检人群作为研究对象.共纳入152例确诊的MS患者及90名健康对照人群进行研究.测量体质指数(BMI)、收缩压(SBP)、舒张压(DBP)等人体测量学参数;检测血糖(GLU)、血清三酰甘油(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)及C1q水平;比较各组之间的差异,并进行相关性分析.结果MS患者的血清C1q水平(244.34±62.66)mg/L显著高于健康对照人群(202.37±35.92)mg/L(t=-6.250,P=0.000).Spearman相关性分析显示MS患者血清C1q水平(244.34±62.66)mg/L与血清TG水平[2.34(1.89,3.62)]mmol/L(r=0.245,P=0.001)、TC水平(4.91±1.26)mmol/L(r=0.398,P=0.000)、LDL-C水平(3.23±1.03)mmol/L(r=0.325,P=0.000)呈显著正相关;肥胖的MS患者C1q水平(258.92±69.59)mg/L与收缩压(SBP)(144.76±22.94)mmHg(r=0.388,P=0.018)、血清TG水平[2.65(1.87,3.82)]mmol/L(r=0.482,P=0.003)、TC水平(5.18±1.31)mmol/L(r=0.529,P=0.001)均具有显著的正相关关系.以C1q为因变量进行多元逐步回归分析显示在校正性别、年龄等其他混杂因素后,血清TG水平是MS患者(β=0.302,P=0.000)以及肥胖的MS患者(β=0.653,P=0.000)C1q水平的独立影响因素.结论MS患者血清C1q水平显著升高,C1q水平与血脂代谢谱的水平密切相关,血清TG水平为代谢综合征患者C1q水平的独立影响因素.Objectives To analyze the changes of serum complement C1q level in patients with metabolic syndrome (MS) and investigate whether it is associated with lipid metabolism and glycometabolism. Methods In a cross-sectional study, the subjects were selected as the patients and healthy people who went to the second xiangya hospital of central south university from July 2017 to June 2018. A total of 152 MS patients were enrolled and another 90 healthy subjects were enrolled as control group. Anthropometry parameters such as body mass index (BMI), systolic blood pressure (SBP), diastolic blood pressure (DBP) were measured. Serum concentrations of C1q and other biochemical indexes including blood glucose (GLU), triglycerides (TG), total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C) were measured in all groups. The correlations between C1q and these parameters were analyzed by spearman′s rho test and the clinical value of C1q in predicting MS was further evaluated by stepwise multiple linear regression analysis. Results MS group had higher serum C1q levels (244.34±62.66) mg/L compared with the control group (202.37±35.92) mg/L (t=-6.250, P=0.000). C1q levels (244.34±62.66) mg/L were positively associated with TG levels [2.34(1.89, 3.62)] mmol/L (r=0.245, P=0.001), TC levels (4.91±1.26) mmol/L (r=0.398, P=0.000), LDL-C levels (3.23±1.03) mmol/L (r=0.325, P=0.000) in MS group, While C1q levels (258.92±69.59) mg/L were positively associated with SBP (144.76±22.94) mmHg (r=0.388, P=0.018), TG levels [2.65(1.87, 3.82)] mmol/L (r=0.482, P=0.003), TC levels (5.18±1.31) mmol/L (r=0.529, P=0.001) in MS patients with obesity. The stepwise multiple regression analysis showed that TG levels were independently correlated with serum C1q levels both in MS patients (β=0.302, P=0.000) and in MS patients with obesity (β=0.653, P=0.000) after adjusting for age, gender and other biochemical markers. Conclusions MS patients had higher C1q levels than healthy subjects a

关 键 词：补体C1Q 代谢综合征 肥胖 体质指数 三酰甘油 

分 类 号：R589[医药卫生—内分泌]