KLF8表达修饰及致瘤机制研究进展  

Research Progress of KLF8 Expression,Modification and Oncogenic Mechanism

作　　者：刘善辉 何魏 马文斐 李兰兰[1,2,3] 卢建中 陶燕[1,2,3] 张静 付生军[1,2,3] LIU Shan-hui;HE Wei;MA Wen-fei;LI Lan-lan;LU Jian-zhong;TAO Yan;ZHANG Jing;FU Sheng-jun(Institute of Urology,Lanzhou University Second Hospital,Lanzhou 730030,China;Key Laboratory of Urological Disease of Gansu Province,Lanzhou 730030,China;Institute of Gansu Nephro-Urological Clinical Center,Lanzhou 730030,China;The Second Clinical Medical College of Lanzhou University,Lanzhou 730050,China)

机构地区：[1]兰州大学第二医院泌尿外科研究所,兰州730030 [2]甘肃省泌尿系统疾病研究重点实验室,兰州730030 [3]甘肃省泌尿系疾病临床医学中心,兰州730030 [4]兰州大学第二临床医学院,兰州730030

出　　处：《中国生物工程杂志》2019年第8期80-85,共6页China Biotechnology

基　　金：兰州大学第二医院“萃英科技创新”计划(CY2018-QN13);兰州大学第二临床医学院“萃英学子科研培育计划”(CYXZ-08)的资助

摘　　要：KLF8(Krüppel-like factor 8)是Krüppel样转录因子家族最新成员。KLF8广泛表达于皮肤、脂肪、食道等组织中。早期研究表明,KLF8蛋白具有转录抑制活性,在胚胎发育过程中起重要作用。而近些年大量的研究发现KLF8在多种肿瘤组织中异常高表达,具有转录活化因子活性,可通过对细胞增殖、迁移、侵袭、EMT、细胞干性等多项生理过程调控促进肿瘤发生发展。综述了近年来KLF8研究进展,系统阐述了KLF8表达修饰调控及致瘤机制,为全面深入了解KLF8在肿瘤中作用及后续相关研究提供参考。KLF8 (Krüppel-like factor 8) is a novel member of the Krüppel-like transcription factor family. KLF8 is widely expressed in different tissues such as skin, adipose, and esophagus, etc. Early studies showed that KLF8 protein was possessed of transcriptional inhibitory activity and played an important role in embryonic development. In recent years, increasing studies indicated that KLF8 was highly expressed ubiquitously in various types of tumor tissues, and acted as a transcriptional activator. KLF8 could promote tumorigenesis process through regulation of cell proliferation, migration, invasion, EMT, and cancer cells stemness. This article will review the research progress of KLF8 in recent years and systematically expound KLF8 expression regulation and its oncogenic mechanism. It may provide a reference for comprehensive understanding and further study of KLF8 in tumorigenesis.

关 键 词：KLF8 转录活化因子 EMT 细胞干性 

分 类 号：Q78[生物学—分子生物学]