一锅法合成2-苄基-2,3-丁二烯腈类化合物  

One-pot Synthesis of 2-Benzyl-2,3-butadienenitrile Compounds

作　　者：吴海建[1] 杜达敏 王治明[1] 王钰蓉 WU Hai-jian;DU Da-min;WANG Zhi-ming;WANG Yu-rong(School of Advanced Study,Taizhou University, Taizhou 318000, China;School of Electronics & Information Engineering, Taizhou University, Taizhou 318000, China;College of Pharmaceutical Science, Zhejiang Chinese Medical University, Hangzhou 311400, China)

机构地区：[1]台州学院高等研究院,浙江台州318000 [2]台州学院电子与信息工程学院,浙江台州318000 [3]浙江中医药大学药学院,浙江杭州311400

出　　处：《合成化学》2019年第9期712-716,共5页Chinese Journal of Synthetic Chemistry

基　　金：国家自然科学基金资助项目(21372033)

摘　　要：氮气保护下,以(三苯基膦)乙腈、苄基溴、乙酰氯为原料,三乙胺为碱,在二氯甲烷中经一锅法反应合成了12个2-苄基-2,3-丁二烯腈类化合物( 3a^3l ),其中 3b^3l 为新化合物,其结构经 1 H NMR, 13 C NMR和HR-MS(ESI)表征。A series of 2-benzyl-2,3-butadienenitrile compounds( 3a^3l ) were synthesized in one-pot by reaction of(triphenylphosphoranylidene)acetonitrile, benzyl bromide and acetyl chloride, using triethylamine as base and dichlorimethane as solvent. Among them, 5b^5l were new compounds. The structures were characterized by 1 H NMR, 13 C NMR and HR-MS(ESI).

关 键 词：(三苯基膦)乙腈 三乙胺 一锅法 2-苄基-2 3-丁二烯腈 合成 

分 类 号：O625.1[理学—有机化学] O622.1[理学—化学]