急性上呼吸道感染严重程度与患者鼻腔灌洗液中白介素-8和嗜中性粒细胞含量的相关性分析  

Relationship between Severity of Actual Upper Respiratory Infection and Content of Interleukin-8 and Neutrophil in Nasal Lavage

作　　者：向垣诚 XIANG Yuan-cheng(Department of Respiratory medicine,People's Hospital of Yibin County,Sichuan 644440)

机构地区：[1]四川省宜宾县人民医院呼吸内科,四川宜宾644440

出　　处：《医学临床研究》2019年第8期1460-1461,1465,共3页Journal of Clinical Research

摘　　要：【目的】探讨急性上呼吸道感染严重程度与患者鼻腔灌洗液中白介素-8(IL-8)和嗜中性粒细胞含量的相关性。【方法】收集784例急性上呼吸道感染患者,采用威斯康辛上呼吸道症状调查(WURSS)-21评分将患者分为轻度、中度和重度,检测并比较三组鼻腔灌洗液中IL-8和嗜中性粒细胞含量,并分析其与急性上呼吸道感染严重程度的相关性。【结果】784例患者中轻度137例、中度339例和重度308例。轻度、中度及重度上呼吸道感染患者IL-8水平、嗜中性粒细胞百分比依次升高,且组间比较差异有统计学意义(P<0.05)。相关性分析显示: IL-8和嗜中性粒细胞与急性上呼吸道感染严重程度呈显著正相关(r=0.32,P=0.001;r=0.28,P=0.002)。IL-8和嗜中性粒细胞与急性上呼吸道感染鼻症状严重程度相关:流鼻涕(r=0.13,P=0.001;r=0.18,P=0.003),鼻塞(r=0.15,P=0.003;r=0.14,P=0.028)、喷嚏(r=0.02,P=0.001;r=0.01,P=0.031)、声音嘶哑(r=0.02,P=0.017;r=0.03,P=0.034)。【结论】IL-8和嗜中性粒细胞与急性上呼吸道感染期间鼻部症状严重程度相关,可作为急性上呼吸道感染严重程度的监测指标。【Objective】To explore the correlation between the severity of acute upper respiratory infection and the content of interleukin-8 (IL-8) and neutrophils in nasal lavage fluid.【Methods】A total of 784 patients with acute upper respiratory tract infection were included and the contents of IL-8 and neutrophils in nasal lavage fluid were detected.The severity of upper respiratory tract infection was assessed by the Wisconsin wurss-21 survey.According to wurss-21 scores,the patients were divided into three groups: mild,moderate and severe.The content of IL-8 and neutrophils from the three groups were compared,and their relationship with the severity of acute upper respiratory tract infection was also conducted.【Results】Of 784 patients,137 were mild,339 were moderate,and 308 were severe.The content of Il-8 and neutrophils were positively correlated with the severity of acute upper respiratory tract infection.Correlation analysis showed that IL-8 and neutrophils were significantly positively correlated with the severity of acute upper respiratory tract infection (r=0.32,P=0.001;r=0.28,P=0.002).Il-8 and neutrophils were associated with nasal symptom severity of acute upper respiratory tract infection symptoms,including running nose (r=0.13,P=0.001;r=0.18,P=0.003),nasal obstruction (r=0.15,P=0.003;r=0.14,P=0.028),sneezing (r=0.02,P=0.001;r=0.01,P=0.031)and hoarseness (r=0.02,P= 0.017);r=0.03,P=0.034).【Conclusion】Il-8 and neutrophils are associated with the severity of nasal symptoms during acute respiratory infection.Thus can be used as a monitoring indicator for the severity of acute upper respiratory tract infections.

关 键 词：呼吸道感染/病理生理学 细胞因子类 

分 类 号：R563.1[医药卫生—呼吸系统]