正电子计算机断层显像骨显像剂氟[18F]化钠的药动学和显像效果研究  

Pharmacokinetics and Imaging Effect of PET Bone Imaging Agent Sodium [18F]Fluoride

作　　者：郭飞虎 陈雪祺[2] 刘萌[2] 徐晓敏 冯婷婷 黄宪男 杜建冬 姜华 成伟华 吴建爽 王成龙 李艳涛 梁巍 王荣福[2,3] 樊红强 张春丽[2] GUO Fei-hu;CHEN Xue-qi;LIU Meng;XU Xiao-min;FENG Ting-ting;HUANG Xian-nan;DU Jiandong;JIANG Hua;CHENG Wei-hua;WU Jian-shuang;WANG Cheng-long;LI Yan-tao;LIANG Wei;WANG Rong-fu;FAN Hong-qiang;ZHANG Chun-li(High Tech of Atom Co.,Ltd.,Beijing 102413,China;Peking University First Hospital,Beijing 100034,China;Peking University International Hospital,Beijing 102206,China)

机构地区：[1]原子高科股份有限公司,北京102413 [2]北京大学第一医院,北京100034 [3]北京大学国际医院,北京102206

出　　处：《中国药学杂志》2019年第16期1317-1322,共6页Chinese Pharmaceutical Journal

摘　　要：目的氟[18F]化钠是一种正电子计算机断层显像(PET)骨显像剂,主要用于诊断成骨活性有改变的病灶。本实验旨在考查氟[18F]化钠的药动学性质,并通过PET显像研究其诊断效果。方法首先制备氟[18F]化钠注射液,并对其进行质量控制,然后研究其在新西兰兔体内的血液清除情况和血浆蛋白结合率,进行氟[18F]化钠PET和99Tcm-MDPSPECT显像的随机对照试验,并对显像效果进行比较。结果制备了氟[18F]化钠注射液,检验结果均符合质控要求。氟[18F]化钠在血液中清除相半衰期为37min,在体内的清除率(CL)为56mL·min^-1·kg^-1,血浆蛋白结合率为0.57%。2种显像方式均可见全身骨骼,但氟[18F]化钠PET显像给药后30min就可获得良好的显像效果,骨骼部位显示更为清晰,骨骼部位与肌肉的放射性摄取比明显高于99Tcm-MDP。结论氟[18F]化钠PET骨显像性能优于99Tcm-MDPSPECT,本实验为氟[18F]化钠PET用于骨显像的临床应用提供了实验依据。OBJECTIVE Sodium [18F]fluoride is a radioactive diagnostic agent for positron emission tomography ( PET) indicated for imaging of bone to define areas of altered osteogenic activity.To investigate the pharmacokinetic properties of sodium [18F]fluoride,and to study its diagnostic effects by PET imaging.METHODS This study was focused on the preparation and the quality control of sodium [18F]fluoride injection,the blood clearance and plasma protein binding rate of sodium [18F]fluoride in New Zealand rabbits,the randomized controlled trial of sodium [18F]fluoride PET and 99 Tcm-MDP SPECT imaging,and comparing of the imaging results.RESULTS Sodium [18F]fluoride was prepared,the test results conformed to the requirements of the quality control.The half-life of blood clearance phase was 37 min,the clearance rate in the body was 56 mL·min^- 1·kg^- 1,and the plasma protein binding rate was 0.57%.From both sodium [18F]fluoride PET and 99 Tcm-MDP SPECT imaging,the whole body skeleton were visible.However,it only took 30 min for sodium [18F]fluoride to present excellent imaging with clearer bone after administration.The radioactive uptake ratio ( T /NT) of sodium [18F]fluoride between the bone and the muscle was significantly higher than the T /NT of 99 Tcm-MDP.CONCLUSION Sodium [18F]fluoride PET is superior to 99 Tcm-MDP SPECT for bone imaging.This study provides an experimental basis for the clinical application of sodium [18F]fluoride PET in the bone imaging.

关 键 词：正电子计算机断层显像 骨显像 氟[18F]化钠 药动学 药效学 

分 类 号：R969.1[医药卫生—药理学]