Recent advances in autofluorescence-free biosensing and bioimaging based on persistent luminescence nanoparticles  

作　　者：Qiaosong Lin Zhihao Li Quan Yuan 

机构地区：[1]Key Laboratory of Analytical Chemistry for Biology and Medicine (Ministry of Education), College of Chemistry and Molecular Sciences, Wuhan University

出　　处：《Chinese Chemical Letters》2019年第9期1547-1556,共10页中国化学快报（英文版）

基　　金：supported by the National Natural Science Foundation of China (No. 21675120);the National Key R&D Program of China (Nos. 2017YFA0208000, 2016YFF0100800);the National Postdoctoral Program for Innovative Talents (No. BX20180223);the National Basic Research Program of China (973 Program, No. 2015CB932600);the Ten Thousand Talents Program for Young Talents

摘　　要：Persistent luminescence nanoparticles (PLNPs) are a series of emerging luminescent nanomaterials which can emit persistently after ceasing the external excitation. Due to the long decay time of persistent luminescence, the background autofluorescence in complex sample and tissues can be effectively eliminated, thus significantly improving the sensitivity of bioanalysis. Besides, such a long decay time of luminescence also makes PLNPs valuable for long-term bioimaging. Benefiting from these merits, PLNPs have been widely used for biomedical applications, especially biosensing and bioimaging. In this review,we conclude the progress in the application of PLNPs at biosensing and bioimaging in recent years, and also provide our understanding of the prospects.Persistent luminescence nanoparticles (PLNPs) are a series of emerging luminescent nanomaterials which can emit persistently after ceasing the external excitation. Due to the long decay time of persistent luminescence, the background autofluorescence in complex sample and tissues can be effectively eliminated, thus significantly improving the sensitivity of bioanalysis. Besides, such a long decay time of luminescence also makes PLNPs valuable for long-term bioimaging. Benefiting from these merits, PLNPs have been widely used for biomedical applications, especially biosensing and bioimaging. In this review,we conclude the progress in the application of PLNPs at biosensing and bioimaging in recent years, and also provide our understanding of the prospects.

关 键 词：Analysis BIOSENSING BIOIMAGING PERSISTENT LUMINESCENCE NANOPARTICLES 

分 类 号：O6[理学—化学]