新精神活性物质哌异丙基酯的识别与检验  

The Identification of a New Psychoactive Substance Isopropylphenidate

作　　者：钱振华[1] 赵彦彪[1] 贾薇[2] 刘翠梅[2] QIAN Zhenhua;ZHAO Yanbiao;JIA Wei;LIU Cuimei(Institute of Forensic Science,Ministry of Public Security,Beijing 100038,China;Drug Intelligence and Forensic Technology Center,Ministry of Public Security,Beijing 100193,China)

机构地区：[1]公安部物证鉴定中心,北京100038 [2]公安部禁毒情报技术中心,北京100193

出　　处：《中国司法鉴定》2019年第5期15-20,共6页Chinese Journal of Forensic Sciences

基　　金：中央级公益性科研院所基本科研业务费专项资金（No.2017JB030）

摘　　要：目的基于超高效液相色谱-串联四极杆飞行时间质谱(UPLC-Q-TOFMS)法、气相色谱质谱联用(GC-MS)法和核磁共振(NMR)法识别未知的新精神活性物质。方法未知样品分别用合适的溶剂溶解,运用UPLC-Q-TOFMS、GC-MS和NMR分析检测。结果综合UPLC-Q-TOFMS、GC-MS和NMR的分析结果,最终确认该物质为哌醋甲酯、哌乙酯的类似物-哌异丙基酯,并对其在电喷雾正离子(ESI+)-碰撞诱导解离(CID)和电子轰击源(EI)模式下的碎裂机理进行了详细阐述。结论新精神活性物质层出不穷,该方法可为同类样品的推断、鉴定提供较好的依据。Objective To identify a new psychoactive substance by the comprehensive analysis of ultra performance liquid chromatography-quadrupole time-of-flight-mass spectrometry(UPLC-Q-TOF MS),gas chromatography-mass spectrometry(GC-MS)and nuclear magnetic resonance(NMR)spectroscopy.Method The unknown sample was dissolved with proper solvent,then analyzed by the three analytical techniques.Result The unknown substance was identified as a new psychoactive substance,an analogue of methylphenidate and ethylphenidate,isopropylphenidate.Moreover,the MS fragmentations of isopropylphenidate produced in the electrospray ionization(ESI)collision-induced dissociation(CID)mode and the electron ionization(EI)mode were studied respectively.Conclusion Under the situation that new psychoactive substances keep emerging,the current study provides a solution to the identification of new methylphenidate analogues.

关 键 词：新精神活性物质 哌异丙基酯 超高效液相色谱-串联四极杆飞行时间质谱(UPLC-Q-TOFMS) 气相色谱质谱联用(GC-MS) 核磁共振(NMR) 

分 类 号：DF795.4[医药卫生—法医学]