肺表面活性物质对不同性别新生儿呼吸窘迫综合征的治疗效果  

Efficacy of Pulmonary Surfactant Therapy in Different Genders Neonates with Respiratory Distress Syndrome

作　　者：谭卉晗 王鉴 TAN Huihan;WANG Jian(0x09Guizhou Medical University, Guiyang 550004, Guizhou, China;Department of Neonatology,the Affiliated Hospital of Guizhou Medical University, Guiyang 550004, Guizhou, China)

机构地区：[1]贵州医科大学,贵州贵阳550004 [2]贵州医科大学附院新生儿科,贵州贵阳550004

出　　处：《贵州医科大学学报》2019年第9期1074-1078,共5页Journal of Guizhou Medical University

基　　金：贵州省科学技术基金项目[黔科合J字(2009)2160]

摘　　要：目的:探讨肺泡表面活性物质(PS)对不同性别呼吸窘迫综合征(NRDS)早产儿的治疗效果。方法: 112例早产NRDS患儿,男94例、女28例,记录两组NRDS患儿出生体质量、胎龄、Apgar评分、母亲产前是否使用激素等基本临床资料,观察PS治疗前及治疗后6、12及24 h的氧分压(PaO 2)、氧合指数(P/F)、治疗后并发症[肺部感染、气胸、动脉导管未闭(PDA)、支气管肺发育不良(BPD)、颅内出血(ICH)、肺出血]、治疗时间(机械通气时间、氧疗时间、住院时间)及死亡例数发生情况。结果:各组患儿经PS治疗后6、12及24 h时的血液PaO 2均较治疗前升高,差异有统计学意义( P <0.05);女性患儿治疗后各时间点血液PaO 2较男性患儿组高,在治疗后6 h时比较差异有统计学意义( P <0.05);女性患儿及所有患儿经治疗后P/F较本组治疗前上升,差异有统计学意义( P <0.05);男、女性患儿PS治疗后肺部感染、气胸、PDA、BPD、ICH发生比例比较,差异无统计学意义( P >0.05);女性患儿发生肺出血比例较男性患儿低,差异有统计学意义( P <0.05);女性患儿机械通气时间、氧疗时间均低于男性患儿,差异有统计学意义( P <0.05);女性患儿住院时间均值低于男性患儿,但差异无统计学意义( P >0.05);男性患儿PS治疗后死亡比例明显高于女性患儿,差异有统计学意义( P <0.05)。结论: PS对不同性别NRDS早产患儿疗效不同,对女性患儿的治疗效果优于男性。Objective: To investigate the clinical efficacy of pulmonary surfactant (PS) therapy in different genders premature infant diagnosed with respiratory distress syndrome (NRDS). Methods: 112 premature infants diagnosed with NRDS (94 males and 28 females), recording clinical data, including birth weight, gestational age, Apgar score, antepartum hormone treatment in mother or not. Observing PaO 2, P/F, postoperative complications (pulmonary infection, aerothorax, PDA, BPD, ICH and pulmonary hemorrhage), treatment time (mechanical ventilation time, oxygen treatment time and hospitalization time) and number of death cases before treatment and 6 h, 12 h and 24 h after PS treatment. Results: All infant patients showed an PaO 2 improvement in blood 6 h, 12 h and 24 h after PS treatment compared with before treatment, differences were statistically significant ( P <0.05);blood PaO 2 of female newborns was higher than that of male newborns at each time point after treatment, and the difference was statistically significant only 6h after treatment ( P <0.05). Compared with before treatment, P/F increased in female newborns and in general newborns after treatment compared with before treatment in its own group, difference was statistically significant ( P <0.05);after PS treatment, incidence number of pulmonary infection, aerothorax, PDA, BPD, ICH between male and female infant patients showed no statistical significance (P >0.05);female infant patients showed less pulmonary hemorrhage rate than male counterparts, difference was statistically significant ( P< 0.05). The mechanical ventilation time and oxygen therapy time of female infant patients were shorter than that of males, difference was statistically significant ( P< 0.05). The mean hospitalization time of female infant patients was less than that of males, difference was not statistically significant ( P >0.05). The death rate of male infant patients was significantly higher than that of females, difference was statistically significant ( P< 0.05). Conclusions: PS has

关 键 词：肺表面活性物质 新生儿呼吸窘迫综合征 新生儿 性别 血气分析 

分 类 号：R722[医药卫生—儿科]