MUM1蛋白表达与黑色素瘤的临床病理特征相关性分析  

Analysis of the Correlation between the Expression of MUM1 Protein and the Clinicopathological Features of Melanoma

作　　者：赵燕 杨文秀[1] 冯江龙 ZHAO Yan;YANG Wenxiu;FENG Jianglong(Department of Pathology,Guizhou Medical University,Guiyang 550004,Guizhou,China;Department of Ophthalmology,Guizhou People′s Hospital,Guiyang 550002,Guizhou,China)

机构地区：[1]贵州医科大学临床医学院病理学教研室,贵州贵阳550004 [2]贵州省人民医院眼科,贵州贵阳550002

出　　处：《贵州医科大学学报》2019年第9期1101-1104,共4页Journal of Guizhou Medical University

基　　金：贵阳市科技局贵州医科大学联合基金(GY2016-4)

摘　　要：目的:探讨多发性骨髓瘤癌基因(MUM1)蛋白表达与黑色素瘤(MM)患者临床病理特征的关系。方法:收集60例MM患者的临床病理资料,以同期的肿瘤切缘正常组织60例作为对照组,采用免疫组织化学法检测MUM1蛋白表达。结果: MUM1阳性信号定位于细胞核,表现为细胞核的棕褐色颗粒状信号;MM组患者的MUM1蛋白阳性率明显高于对照组,差异有高度统计学意义( P< 0.001);MUM1蛋白阳性组和阴性组之间的肿瘤转移、复发差异有统计学意义( P <0.05或 P <0.01),但性别、年龄、吸烟、肿瘤直径、TNM分期、肿瘤分化的差异无统计学意义( P >0.05)。结论: MUM1蛋白阳性表达与MM肿瘤的复发、转移有关,可能是MM不良预后的相关因素。Objective: To explore the relationship and significance between the expression of MUM1 and the clinicopathological characteristics of melanoma. Methods: The clinical pathological diagnosis information of 60 cases of MM patients was collected while 60 patients with normal tumor margin were selected as control group. MUM1 protein expression of them was detected by immunohistochemistry. Results: MUM1 positive signal was located in the nucleus and manifested as the brown granular signal of the nucleus.The positive rate of MUM1 protein in the MM group was significantly higher than that in the control group,and the difference was highly statistically significant ( P <0.001).There were statistically significant differences in tumor metastasis and recurrence between the MUM1 protein-positive group and the negative group ( P <0.05 or P <0.01),but no statistically significant differences in gender,age,smoking,tumor diameter,TNM stage and tumor differentiation ( P >0.05). Conclusion: MUM1 protein can be used as a diagnostic index of the MM.MUM1 protein positive expression is associated with the recurrence and metastasis of MM tumor,which may be a related factor for the poor prognosis of malignant melanoma.

关 键 词：多发性骨髓瘤 黑色素瘤 免疫组织化学 蛋白 病理特征 

分 类 号：R320.67[医药卫生—人体解剖和组织胚胎学] R310.44[医药卫生—基础医学]