采用静息态功能磁共振研究先天性重度感音神经性耳聋患儿相关脑区的ALFF值  

Investigating the changes of ALFF of hearing related cortex of infants with sensorineural hearing loss by using fMRI

作　　者：刘梦秋 刘婕 刘影[1] LIU Mengqiu;LIU Jie;LIU Ying(Department of Radiology, the First Affiliated Hospital of University of Science and Technology of China (Anhui Provincial Hospital), Hefei 230001, China)

机构地区：[1]中国科学技术大学附属第一医院(安徽省立医院)

出　　处：《磁共振成像》2019年第9期650-654,共5页Chinese Journal of Magnetic Resonance Imaging

基　　金：安徽省2017年公益性技术应用研究联动计划项目基金(编号:1704f0804003)~~

摘　　要：目的采用静息态功能磁共振研究0~4岁的双侧先天性重度感音神经性耳聋患儿全脑振幅低频波动(amplitude of low-frequency fluctuation,ALFF)值的变化情况。材料与方法纳入0~4岁双侧先天性重度感音神经性耳聋患儿25例,正常听力组20名,以2岁为大脑发育的关键期分为4组:0~2岁耳聋患儿16例,0~2岁对照组9名;2~4岁耳聋患儿9例,2~4岁对照组11名。采用GE 3.0 T磁共振成像仪对耳聋组和正常组进行静息态功能磁共振扫描,采用ALFF分析静息态功能磁共振数据。结果 0~2岁耳聋患儿与0~2岁正常被试的ALFF相比ALFF值升高脑区有左侧楔前叶、右侧额上回、右侧枕中回、右侧顶上小叶,ALFF值降低的脑区有左侧颞上回、左侧额下回,2~4岁耳聋患儿与2~4岁正常被试的ALFF相比ALFF值升高的脑区有左侧前扣带回、左侧颞下回。ALFF值降低的脑区有左侧额下回、左侧颞上回。2~4岁耳聋患儿和0~2岁耳聋患儿的ALFF相比ALFF值升高的脑区有左侧颞上回、左侧额下回、岛叶,ALFF值降低的脑区有右侧内侧额回、左侧颞下回。结论 0~4岁的先天性重度感音神经性耳聋患儿听觉、语言等相关脑区可能发生了功能重塑,功能磁共振能对人工耳蜗术前评估及预后的判断提供一定的帮助。Objective: To study the changes of low frequency amplitude(ALFF) in hearing related brain regions of children with bilateral congenital severe sensorineural deafness(BCSSD) using resting-state functional magnetic resonance imaging(rs-fMRI). Materials and Methods: Twenty-five children(0—4 years old) with BCSSD were recruited in this study and they were divided into two groups: 16 "younger" children with ages below 2 years old and 9 "older" children with ages above 2 years old. Twenty age-matched healthy children(9 in the "younger" group and 11 in the "older" group) were also recruited as controls. All rs-fMRI scans were performed on a 3.0 T GE scanner(discovery 750 w). Data were analyzed to produce ALFF values in different brain regions. Results: In the "younger" group, patients with BCSSD had higher ALFF values compared to healthy controls in left anterior cuneiform lobe, right superior frontal gyrus, right middle occipital gyrus and right parietal lobule. Patients also showed lower ALFF values in left superior temporal gyrus and left inferior frontal gyrus. In the "older" group, patients with BCSSD had higher ALFF values in left anterior cingulate gyrus and left infratemporal gyrus. On the contrary, lower ALFF values were found in left inferior frontal gyrus and left superior temporal gyrus in patients, compared to healthy controls. Comparisons were also performed within the patient group, our results showed that "younger" patients had higher ALFF values in left superior temporal gyrus, left inferior frontal gyrus and insula, and had lower ALFF values in right medial frontal gyrus and left inferior temporal gyrus, compared to "older" patients. Conclusions: The results in this study indicate that functional remodeling may occur in the auditory sensory cortex of children with BCSSD. Functional magnetic resonance imaging can be used as a potential tool to assist preoperative evaluation and prognosis judgement of cochlear implants.

关 键 词：静息态 低频振幅 先天性感音神经性耳聋 磁共振成像 

分 类 号：R445.2[医药卫生—影像医学与核医学] R764.4[医药卫生—诊断学]