间氨基苯酚N-烷基衍生物的合成新方法  

A New Synthetic Process for N,N-Dialkyl-m-aminophenol Derivatives

作　　者：张龙 陆晟 茆勇军[1] 沈永嘉[2] ZHANG Long;LU Sheng;MAO Yong-jun;SHEN Yong-jia(College of Chemical Engineering, Shanghai University of Engineering and Technology, Shanghai 201620, China2.Institute of Fine Chemicals, East China University of Science and Technology, Shanghai 200237, China)

机构地区：[1]上海工程技术大学化学化工学院,上海201620 [2]华东理工大学精细化工研究所,上海200237

出　　处：《染料与染色》2019年第4期40-42,18,共4页Dyestuffs and Coloration

摘　　要：开发了一种合成间氨基苯酚N-烷基衍生物的新方法。以间二硝基苯与过量的苯甲醇在碳酸钾的存在下发生亲核取代反应,生成的产物(间硝基苄基苯酚)不分离,直接转移到压力釜中,添加乙醛或正丁醛,经氢化-裂解-还原-胺化反应得到间氨基苯酚N-烷基衍生物,同时副产甲苯。整个反应过程不需要用水。A new synthetic process for N,N-dialkyl-m-aminophenol was developed.The nucleophilic substitution reaction of m-dinitrobenzene with benzyl alcohol in the presence of potassium carbonate was conducted,whose product(mainly m-nitrobenzyl phenol)without separation was transferred directly to an autoclave together with acetaldehyde or butyraldehyde to afford N,N-diethyl,or N,N-dibutyl-m-aminophenol by hydrogenation-cracking-reduction-amination together with by-product toluene.The whole reaction processes does not need water.

关 键 词：间二硝基苯 间硝基苄基苯酚 氢化-裂解-还原胺化反应 间氨基苯酚N-烷基衍生物 

分 类 号：TQ612.1[化学工程—精细化工]