益胃化浊方联合叶酸片、亮菌口服溶液治疗胃癌前病变30例  

Yiwei Huazhuo decoction combined with folic acid tablets and armillariella oral solution in treating 30 cases of precancerous lesion of gastric cancer

作　　者：孙涛[1] 周兰[1] 朱玉[1] 姚诗清[1] 汪超[1] 何蕾[1] 柳雯[1] Sun Tao;Zhou Lan;Zhu Yu;Yao Shiqing;Wang Chao;He Lei;Liu Wen

机构地区：[1]蚌埠医学院第一附属医院

出　　处：《中医临床研究》2019年第21期74-77,共4页Clinical Journal Of Chinese Medicine

基　　金：蚌埠医学院自然科学基金面上项目(BYKY17103)

摘　　要：目的:观察益胃化浊方联合叶酸片、亮菌口服溶液治疗胃癌前病变的疗效。方法:将就诊于我科的60例胃癌前病变患者,随机分为对照组与治疗组。对照组予以叶酸片1片,口服,每日3次;亮菌口服溶液2支,口服,每日3次;治疗组在此基础之上,给予益胃化浊方每日1剂,水煎煮400mL,分早晚2次口服。1个月为1个疗程,连服3个疗程。结果:治疗前两组胃蛋白酶原Ⅰ(PGⅠ)、胃蛋白酶原Ⅱ(PGⅡ)、胃泌素17(G-17)血清水平差异无统计学意义(P>0.05);治疗后,与对照组相比治疗组的胃蛋白酶原Ⅰ(PGⅠ)升高,胃蛋白酶原Ⅱ(PGⅡ)、胃泌素17(G-17)减低,差异有统计学意义(P<0.05)。治疗前两组胃脘疼痛、嗳气、腹胀中医症状积分差异无统计学意义(P>0.05);治疗后,与对照组相比治疗组的胃脘疼痛、嗳气、腹胀中医症状积分减低,差异有统计学意义(P<0.01)。治疗前两组碳13尿素呼气试验检测率差异无统计学意义(P>0.05);治疗后相对于对照组(χ^2=4.286,P=0.038),有统计学意义。总有效率(χ^2=5.711,P=0.017)。总结:益胃化浊方联合叶酸片、亮菌口服溶液治疗胃癌前病变较单纯使用叶酸片、亮菌口服溶液治疗有更好的疗效。Objective:To observe the curative effect of Yiwei Huazhuo decoction combined(益胃化浊方)with folic acid tablets and armillariella oral solution on PLGC.Method:60 patients with gastric precancerous lesions in our hospital were randomly divided into the control group(30 cases)and the treatment group(30 cases).The control group was given one tablet of folic acid tablets each time,three times a day and two bottles of armillariella oral solution each time,three times a day;The treatment group was given one Yiwei Huazhuo decoction(益胃化浊方)of 400 mL,on the basis of the medication of the control group.They were treated for three courses,one course lasted one month.Results:The pepsinogenⅠ(PGⅠ),pepsinogenⅡ(PGⅡ)and gastrin-17(G-17)in the two groups had no significant differences before treatment(P>0.05).After treatment,compared with those of the control group,pepsinogenⅠ(PGⅠ)increased,while pepsinogenⅡ(PGⅡ)and gastrin-17(G-17)decreased in the treatment group,which was of significant differences(P<0.05).The stomach pain,belching,abdominal distension of TCM symptoms in the two groups was of no significant difference before treatment(P>0.05);After treatment,compared with those in the control group,the scores for TCM symptoms like stomach pain,belching,abdominal distension decreased in the treatment group,which was of significant differences(P<0.01).There was no statistical difference in the detection rate of carbon 13 urea breath test before treatment(P>0.05).Compared with the control group(χ^2=4.286,P=0.038),there was a statistical difference after treatment.Total effective rate was(χ^2=5.711,P=0.017).Conclusion:The effect of Yiwei Huazhuo decoction(益胃化浊方)combined with folic acid tablets and armillariella oral solution had better effect in treating gastric precancerous lesions than folic acid tablets and armillariella oral solution alone.

关 键 词：胃癌前病变 益胃化浊 湿浊 瘀血 

分 类 号：R259[医药卫生—中西医结合]