子宫内膜异位症患者盆腔痛与血清MMPs及CA125水平的相关性  

Correlation between pelvic pain and serum MMPs and CA125 levels in patients with endometriosis

作　　者：蒋红梅[1] Jiang Hongmei(Department of Gynecology and Obstetrics,Jiamusi Central Hospital,Jiamusi 154002,China)

机构地区：[1]佳木斯市中心医院妇产科,154002

出　　处：《国际医药卫生导报》2019年第17期2898-2901,共4页International Medicine and Health Guidance News

摘　　要：目的 探讨子宫内膜异位症患者盆腔痛与血清基质金属蛋白酶(MMPs)及糖蛋白抗原(CA125)水平的相关性。方法 选取本院2016年6月至2019年2月收治的102例子宫内膜异位症患者,依据盆腔疼痛程度分为无疼痛组(30例)、轻度疼痛组(29例)、中度疼痛组(24例)、重度疼痛组(19例)。测定4组血清基质金属蛋白酶2(MMP2)、血清基质金属蛋白酶7(MMP7)、血清基质金属蛋白酶3(MMP3)及血清糖蛋白抗原(CA125)水平,并分析MMP2、MMP7、MMP3及CA125水平与盆腔痛的相关性。结果 4组患者中,无疼痛组血清MMP2、MMP7、MMP3、CA125水平最低,其次是轻度疼痛组、中度疼痛组,重度疼痛组血清MMP2、MMP7、MMP3、CA125 水平最高,差异具有统计学意义(均P< 0.05);经双变量Pearson 相关性分析检验证实,血清MMP2、MMP7、MMP3、CA125 水平与盆腔痛呈正相关(r > 0,P<0.05),即随着血清MMP2、MMP7、MMP3、CA125 水平的升高,子宫内膜异位症患者盆腔痛症状越严重。结论 子宫内膜异位症患者血清中MMPs、CA125 的异常高表达与盆腔痛的程度密切相关。Objective To investigate the relationship between pelvic pain and serum levels of matrix metalloproteinase (MMPs) and glycoprotein antigen (CA125) in patients with endometriosis. Methods 102 patients with endometriosis admitted in our hospital from June, 2016 to February, 2019 were divided into 4 groups according to the degree of pelvic pain: a non-pain group (n = 30), a mild pain group (n = 29), a moderate pain group (n = 24), and a severe pain group (19 cases). The serum matrix metalloproteinase 2 (MMP2), 7 (MMP7) and 3 (MMP3), as well as serum glycoprotein antigen (CA125), were measured in the four groups. The correlation of the levels of MMP2, MMP7, MMP3 and CA125 with pelvic pain was analyzed. Results The serum levels of MMP2, MMP7, MMP3, and CA125 were the lowest in the non-pain group, followed by those in the mild pain group, the moderate pain group, and the severe pain group, with statistical differences (all P < 0.05). The results of bivariate Pearson correlation analysis showed that serum levels of MMP2, MMP7, MMP3, and CA 125 were positively correlated with pelvic pain (r > 0, P < 0.05), indicating that, with the increase of the serum levels MMP2, MMP7, MMP3, and CA125, the pelvic pain were more severe in the patients. Conclusion The abnormal high expressions of MMPs and CA125 in serum of patients with endometriosis are closely related to the degree of pelvic pain.

关 键 词：子宫内膜异位症 盆腔痛 血清MMPs CA125 相关性 

分 类 号：R711.71[医药卫生—妇产科学]