血小板抗感染的机制研究进展  

Research progress of anti-infective mechanism of platelets

作　　者：张昭远 杨帆[1] 卢年芳 袁霆[1] 张长青[1] Zhang Zhaoyuan;Yang Fan;Lu Nianfang;Yuan Ting;Zhang Changqing(Department of Orthopaedic Surgery,Shanghai Jiao Tong University Affiliated Sixth People’s Hospital,Shanghai 200233,China;Intensive Care Unit,Beijing Electric Power Hospital,Beijing 100073,China)

机构地区：[1]上海交通大学附属第六人民医院骨科,200233 [2]北京电力医院重症医学科,100073

出　　处：《中华关节外科杂志（电子版）》2019年第4期443-447,共5页Chinese Journal of Joint Surgery(Electronic Edition)

基　　金：国家自然科学基金(81572239);上海申康医院发展中心临床科技创新项目(SHDC12016219)

摘　　要：感染是影响人类健康的常见疾病之一,可造成创面不愈合、脓毒症及其他感染性疾病,继而引发多系统器官衰竭而导致死亡。血小板是最常见的血液成分之一,最先发现内皮细胞损伤和病原微生物入侵并产生反应,可内吞病原体、释放抗菌肽和调节机体的免疫反应等。本文就血小板的抗感染机制研究进展作一综述。Infection is one of the most common diseases, which can cause nonhealing wound, sepsis and other infectious diseases, then lead to multisystem organ failure and death. Platelets, one of the most common element of blood, is the first component which detect damage of endothelial cell and invasion of pathogen. In addition, platelets can internalize pathogens, secrete antimicrobial peptides, participate in and orchestrate the immune response. In this article, the research progress of anti-infective mechanism of platelets is reviewed.

关 键 词：血小板 感染 免疫 

分 类 号：R392[医药卫生—免疫学]