脂肪组织巨噬细胞在肥胖诱导的炎症和胰岛素抵抗中的作用  

The role of adipose tissue macrophages in obesity induced inflammation and insulin resistance

作　　者：朱翠松 杨瑜[1] 刘明斌 徐建青[1] 张晓燕[1] ZHU Cui-song;YANG Yu;LIU Ming-bin;XU Jian-qing;ZHANG Xiao-yan(Shanghai Public Health Clinical Center,Shanghai 201508,China)

机构地区：[1]上海市公共卫生临床中心

出　　处：《复旦学报（医学版）》2019年第5期681-686,共6页Fudan University Journal of Medical Sciences

基　　金：国家自然科学基金面上项目(81672018)~~

摘　　要：脂肪组织中促炎性巨噬细胞在肥胖导致的炎症和胰岛素抵抗过程中发挥关键性的作用。在正常的脂肪组织中巨噬细胞主要以抗炎性的M2型巨噬细胞为主,参与维持脂肪组织稳态。然而在肥胖的脂肪组织中M1型巨噬细胞浸润数量大大增加,其分泌的促炎性细胞因子可诱导脂肪组织炎症和胰岛素抵抗的发生。因此巨噬细胞导致的炎症反应被认为是联系肥胖以及肥胖相关代谢综合征的纽带。本文就脂肪组织巨噬细胞在肥胖导致的炎症和胰岛素抵抗中的作用作一综述。Macrophages infiltration in adipose tissue is associated with obesity-induced inflammation and insulin resistance.In lean adipose tissue,the number of M2 macrophages is predominant and M2 macrophages play a role in adipose tissue homeostasis.During obesity,M1 macrophages are dramatically increased in number and secrete pro-inflammatory cytokines,leading to adipose tissue inflammation and insulin resistance.Thus,macrophage-induced inflammation is thought to be a link between obesity and obesity-related metabolic syndrome.This review summarizes the role of adipose tissue macrophages in the pathogenesis of obesity-induced inflammation and insulin resistance.

关 键 词：脂肪组织巨噬细胞 肥胖 炎症 胰岛素抵抗 

分 类 号：R392.12[医药卫生—免疫学]