单纯性慢阻肺与慢阻肺合并肺癌患者肺功能对比研究  

Comparative study of pulmonary function in patients with simple chronic obstructive pulmonary disease(COPD) and COPD combined with lung cancer

作　　者：王治国[1] 冯四平[2] 韩继明[3] WANG Zhi-guo;FENG Si-ping;HAN Ji-ming(Department of Respiratory Medicine,Affiliated Hospital of Yan'an University,Yan'an 716000,China;Department of Pharmacy,Yan'an People's Hospital,Yan'an 716000,China;Medical School of Yan'an University,Yan'an 716000,China)

机构地区：[1]延安大学附属医院呼吸内科,陕西延安716000 [2]延安市人民医院药剂科,陕西延安716000 [3]延安大学医学院,陕西延安716000

出　　处：《延安大学学报（医学科学版）》2019年第3期46-48,共3页Journal of Yan'an University:Medical Science Edition

基　　金：国家自然科学地区基金(81760510)

摘　　要：目的对单纯性慢阻肺与慢阻肺合并肺癌患者进行对比研究。方法收集2015年9月至2017年6月收治入延安大学附属医院的50名慢阻肺急性加重期患者和慢阻肺合并肺癌患者30例为研究对象。对两组患者一般资料、肺功能和临床症状体征进行对比研究。结果在FVC方面两组患者存在显著性差异(t=9.145,P=0.000),单纯慢阻肺患者FVC值高于慢阻肺合并肺癌患者。在FEV1/FVC方面,单纯慢阻肺患者低于慢阻肺合并肺癌患者,存在显著性差异(t=-4.532,P=0.033)。在FEV1占预计值百分比方面两组患者无显著性差异(t=-1.536,P=0.163);在胸痛、痰中带血、肺不张和胸腔积液的比较中,慢阻肺合并肺癌患者人数多于单纯慢阻肺患者,两组患者存在显著性差异(χ^2=7.019,P=0.008;χ^2=10.688,P=0.001;χ^2=5.814,P=0.016;χ^2=4.110,P=0.043)。结论慢阻肺合并肺癌患者的肺功能较单纯慢阻肺患者有显著降低,当慢阻肺患者出现胸痛、痰中带血、肺不张及胸腔积液等临床表现时应该高度警惕肺癌的存在。Objective To compare the study of simple chronic obstructive pulmonary disease (COPD) and COPD with lung cancer.Methods A total of 50 patients with acute exacerbation of COPD and 30 patients with COPD and lung cancer who were admitted to Yan'an University Affiliated Hospital from September 2015 to June 2017 were enrolled.A comparative study of general data,lung function,and clinical signs and symptoms was performed between the two groups.Results There were significant differences between the two groups in the FVC group ( t=9.145,P =0.000).The FVC value of patients with chronic obstructive pulmonary disease was higher than that of patients with chronic obstructive pulmonary disease and lung cancer.In terms of FEV 1/FVC,patients with chronic obstructive pulmonary disease were significantly lower than patients with chronic obstructive pulmonary disease and lung cancer ( t=-4.532,P =0.033).There was no significant difference between the two groups in terms of FEV 1 as a percentage of predicted values ( t=-1.536,P =0.163).In the comparison of chest pain,blood stasis,atelectasis and pleural effusion,the number of patients with chronic obstructive pulmonary disease and lung cancer was more than that of patients with chronic obstructive pulmonary disease.There was a significant difference between the two groups(χ^2 = 7.019,P=0.008;χ^2=10.688,P=0.001;χ^2=5.814,P=0.016;χ^2=4.110,P=0.043 ).Conclusion The lung function of patients with COPD and lung cancer is significantly lower than that of patients with COPD.When COPD patients have chest pain,blood stasis,atelectasis and pleural effusion,they should be highly alert to the presence of lung cancer.

关 键 词：慢阻肺 肺癌 肺功能 

分 类 号：R563.9[医药卫生—呼吸系统] R734.2[医药卫生—内科学]