利用聚乙烯醇缩醛反应接枝季鏻盐制备高分子抗菌材料  

Quaternary phosphonium salts grafting into polyvinyl alcohol by acetalization for antibacterial usage

作　　者：林越威 敖宁建[1,2] LAM Yuetwai;AO Ningjian(Department of Biomedical Engineering, Ji’nan University, Guangzhou 510632, China;Key Laboratory of Biomaterials, Guangdong Provincial Department of Education, Guangzhou 510632, China)

机构地区：[1]暨南大学生命科学技术学院生物医学工程系,广州510632 [2]广东省教育厅生物材料重点实验室,广州510632

出　　处：《功能材料》2019年第9期9001-9005,共5页Journal of Functional Materials

基　　金：国家自然科学基金资助项目(20976068/B060805);广东省科技厅科技计划资助项目(2017A020211006)

摘　　要：聚乙烯醇(PVA)常用作生产伤口敷料的材料,季鏻盐(QPS)具有良好的抗菌作用。研究旨在通过使用缩醛反应,在常温下快速将QPS接枝到PVA中来制备抗菌材料。通过测试材料的热学性能、抗菌性能和细胞毒性,发现该材料具有热塑性并具有良好的抗菌效果,且细胞毒性较低。可以通过注塑成型或熔融沉积成型进行加工,并且适合于抗菌伤口敷料使用。将来可用于制造三维打印伤口敷料。Polyvinyl alcohol is often used as a material for producing wound dressing, and quaternary phosphonium salts have good antibacterial effect. This study aimed to prepare an antibacterial material by grafting quaternary phosphonium salts into polyvinyl alcohol using acetalization reaction, which could occur in low temperature and have high reaction rate. By testing the thermal, antibacterial property and in vitro cytotoxicity of the material, it found that the material was thermoplastic, and had good antibacterial activity and low cytotoxicity. It could be fabricated by using injection modeling or fused deposition molding, and was suitable for antibacterial wound dressing usage. It may be possible to use for producing three dimensional printing wound dressing in the future.

关 键 词：生物材料 聚合物 聚乙烯醇 季鏻盐 缩醛反应 抗菌材料 

分 类 号：TQ317[化学工程—高聚物工业]