补肾强督法联合西药对强直性脊柱炎骶髂关节骨髓水肿及关节功能状态的影响  

Effect of reinforcing kidney and strengthening Du meridian combined with western medicine on bone marrow edema and function of sacroiliac joint in patients with ankylosing spondylitis

作　　者：文政[1] 陆伟 龚春柱[1] 孙勇[1] WEN Zheng;LU Wei;GONG Chun-zhu;SUN Yong(the Seventh Department of Orthopaedics,Pingle Orthopedics Hospital of Shenzhen,Shenzhen,Guangdong,518010,China)

机构地区：[1]深圳平乐骨伤科医院骨七科

出　　处：《颈腰痛杂志》2019年第5期639-641,644,共4页The Journal of Cervicodynia and Lumbodynia

摘　　要：目的分析补肾强督法联合西药对强直性脊柱炎(ankylosing spondylitis,AS)骶髂关节骨髓水肿及关节功能状态的影响。方法将2013年9月~2017年12月于本院就诊的104例AS患者按区化随机法设计分组,分别为观察组(n=54)与对照组(n=50),对照组给予西药(乐松+益赛普)治疗,观察组辅以补肾强督法治疗,对比两组炎症指标、疼痛情况、影像学及一般病情评价指标,并统计不良反应发生率。结果治疗后,两组血沉、C反应蛋白、脊柱痛评分、夜间痛评分及总体感觉评分、骶髂关节水肿SPARCC评分、BASDAI指数和BASFI指数、BASMI指数均有显著改善(P<0.05),且观察组优于对照组,差异有统计意义(P<0.05);但两组骶髂关节MRI SSS评分组内及组间差异、不良反应发生率比较均无统计学意义(P>0.05)。结论补肾强督法联合西药可有效改善AS炎症反应、临床症状及体征,并有效缓解骶髂关节骨髓水肿,但对关节结构性病变无明显影响。Objective To analyze the effect of reinforcing kidney and strengthening Du meridian combined with western medicine on bone marrow edema and function of sacroiliac joint in patients with ankylosing spondylitis(AS).Methods From September 2013 to December 2017,104 patients with AS treated in our hospital were randomly divided into the observation group(n=54)and the control group(n=50).The control group was treated with western medicine(loxoprofen+etanercept),while the observation group was additionally given therapy of reinforcing kidney and strengthening Du meridian based on the treatment of the control group.The inflammatory indicators,pain,imaging and general evaluation indicators were compared between the two groups,and the incidence of adverse reactions was statistically analyzed.Results After treatment,the erythrocyte sedimentation rate,C-reactive protein,spinal pain score,nocturnal pain score and general sensory score,SPARCC score of sacroiliac joint edema,BASDAI index,BASFI index and BASMI index in the two groups were significantly improved(P<0.05),and those of the observation group were better than the control group,the differences were statistically significant(P<0.05).There was no statistically significant difference in sacroiliac joint MRI SSS scores within group or between the two groups or the incidence of adverse reactions between the two groups(P>0.05).Conclusion The therapy of reinforcing kidney and strengthening Du meridian combined with western medicine can effectively improve the inflammatory response,clinical symptoms and signs of AS,and effectively relieve bone marrow edema of the sacroiliac joint,without obvious effect on the structural lesion of the joint.

关 键 词：补肾强督法 强直性脊柱炎 骶髂关节骨髓水肿 关节功能 

分 类 号：R593.23[医药卫生—内科学]