异基因造血干细胞移植后并发癫痫发作的诊治进展  

Epileptic seizures in patients after allogeneic hematopoietic stem cell transplantation

作　　者：王卓[1] 赵慕楠 高素君[1] WANG Zhuo;ZHAO Mu-nan;GAO Su-jun(Department of Hematology,the First Hospital of Jilin University,Changchun 130021,China)

机构地区：[1]吉林大学第一医院肿瘤中心血液科

出　　处：《中国医学前沿杂志（电子版）》2019年第9期14-19,共6页Chinese Journal of the Frontiers of Medical Science(Electronic Version)

基　　金：吉林省卫生人才专项(JLSCZD2019-029)

摘　　要：随着异基因造血干细胞移植(allogenic hematopoietic stem cell transplantation,allo-HSCT)的不断完善和接受移植患者例数的增多,术后出现中枢神经系统并发症的问题逐渐被临床医师所重视,而癫痫发作作为神经系统常见临床表现也不容忽视,其严重影响患者的生存率和生活质量。本文就allo-HSCT后并发癫痫发作的发生率、病因、致痫机制、临床特征、治疗和预后的研究进展进行概括总结,期望增强临床医师对移植后并发癫痫发作的认识和重视程度,早期预防,及时正确处理,最终提高患者生存率,改善预后。Technique in allogeneic hematopoietic stem cell transplantation(allo-HSCT) has greatly advanced over the past decades, which has led to an increase in the number of patients receiving transplantation, the complex surgical procedures place these transplant recipients at high risk for nervous system complications. As a common manifestation of central nervous system, epilepsy has been gradually paid attention to by clinicians because it seriously affects the survival rate and quality of life of those recipients. The aim of this review is to summary the the incidence of seizures after allo-HSCT, and its etiology and mechanism, clinical features, treatment and prognosis, hoping to enhance understanding of concurrent seizures after transplantation, and then doctors can prevent earlier, process timely and correctly, eventually improve the survival and outlook for patients.

关 键 词：异基因造血干细胞移植 癫痫发作 并发症 

分 类 号：R457.7[医药卫生—治疗学] R742.1[医药卫生—临床医学]